Hippocampal and prefrontal processing of network topology to simulate the future

Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new st...

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Veröffentlicht in:	Nature communications Jg. 8; H. 1; S. 14652 - 11
Hauptverfasser:	Javadi, Amir-Homayoun, Emo, Beatrix, Howard, Lorelei R., Zisch, Fiona E., Yu, Yichao, Knight, Rebecca, Pinelo Silva, Joao, Spiers, Hugo J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 21.03.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	631/378/1595/1554 631/378/1595/3922 Adult Brain - diagnostic imaging Brain - physiology Decision trees Female Functional Neuroimaging Hippocampus - diagnostic imaging Hippocampus - physiology Humanities and Social Sciences Humans Hypotheses London Magnetic Resonance Imaging Male multidisciplinary Planning Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Science Science (multidisciplinary) Simulation Spatial Behavior - physiology Spatial Navigation - physiology Spatial Processing - physiology Topology University colleges Young Adult United Kingdom > UK
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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Zusammenfassung:	Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation. The hippocampus is known to support navigation, but how it processes possible paths to aid navigation is unknown. Here Javadi et al . show that entering streets drives hippocampal activity corresponding to the number of future paths, and that prefrontal activity corresponds to path-planning demands.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work.
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms14652