Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form

Hendra virus (HeV) is one of the two prototypical members of the Henipavirus genus of paramyxoviruses, which are designated biosafety level 4 (BSL-4) organisms due to the high mortality rate of Nipah virus (NiV) and HeV in humans. Paramyxovirus cell entry is mediated by the fusion protein, F, in res...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 4; pp. 1056 - 1061
Main Authors:	Wong, Joyce J W, Paterson, Reay G, Lamb, Robert A, Jardetzky, Theodore S
Format:	Journal Article
Language:	English
Published:	United States 26.01.2016
Subjects:	Amino Acid Sequence Crystallography, X-Ray Disulfides - chemistry HEK293 Cells Hendra Virus - chemistry Humans Molecular Sequence Data Protein Conformation Protein Stability Viral Fusion Proteins - chemistry metastable F-protein stabilization F-protein atomic structure Hendra virus membrane fusion paramyxovirus F protein
ISSN:	1091-6490
Online Access:	Get more information
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