Angiogenesis and wound repair: when enough is enough

Review on novel concepts in wound angiogenesis; although more capillaries are generally considered better, new studies suggest otherwise. All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing...

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Published in:	Journal of leukocyte biology Vol. 100; no. 5; pp. 979 - 984
Main Author:	DiPietro, Luisa A.
Format:	Journal Article
Language:	English
Published:	United States John Wiley and Sons Inc 01.11.2016
Subjects:	Angiogenic Proteins - physiology Animals Capillaries - physiology capillary Cicatrix - physiopathology Cicatrix - prevention & control Endothelial Cells - physiology Fetus - physiology Fibrosis Humans inflammation Inflammation - physiopathology Mouth Mucosa - blood supply Mouth Mucosa - injuries Mouth Mucosa - physiology Neovascularization, Physiologic - physiology Pericytes - physiology Prenatal Injuries - physiopathology Regeneration - physiology Review Reviews scar Skin - blood supply Skin - injuries VEGF wound healing Wound Healing - physiology wound healing fibrosis scar capillary inflammation VEGF
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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Abstract	Review on novel concepts in wound angiogenesis; although more capillaries are generally considered better, new studies suggest otherwise. All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes.
AbstractList	All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes. Review on novel concepts in wound angiogenesis; although more capillaries are generally considered better, new studies suggest otherwise. All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes. Review on novel concepts in wound angiogenesis; although more capillaries are generally considered better, new studies suggest otherwise. All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes. All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes.All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate healing is the creation of a new vasculature via angiogenesis. As adult skin wounds heal, a period of rapid and robust capillary growth creates a vascular bed that has many fold more capillaries than does normal tissue. Over time, most of the newly formed capillaries regress, resulting in a final vascular density similar to that of normal skin. Certainly, new capillaries are necessary to bring nutrients, immune cells, and oxygen to healing wounds. Yet, the presumed functional importance of an overabundance of capillaries has recently been challenged, creating questions about whether excess capillary growth is truly necessary for healing. In particular, studies of wounds that heal exceptionally quickly and with less scar formation, such as those in fetal skin and oral mucosa, show that these tissues heal with a reduced angiogenic burst composed of more mature vessels that provide better oxygenation. The level of angiogenesis in wounds often correlates with the inflammatory response, largely because inflammatory cells produce an abundance of proangiogenic mediators. Both the selective reduction of inflammation and the selective reduction of angiogenesis have now been suggested as ways to improve scarring. These concepts link excessive inflammation and the production of a dense but poorly perfused capillary bed to inferior healing outcomes.
Author	DiPietro, Luisa A.
AuthorAffiliation	1 Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois
AuthorAffiliation_xml	– name: 1 Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois
Author_xml	– sequence: 1 givenname: Luisa A. surname: DiPietro fullname: DiPietro, Luisa A.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27406995$$D View this record in MEDLINE/PubMed
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Surg. Res. doi: 10.1006/jsre.2002.6444
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Snippet	Review on novel concepts in wound angiogenesis; although more capillaries are generally considered better, new studies suggest otherwise. All animals heal, and... All animals heal, and the ability to heal is requisite for human health. One aspect of repair that has always been considered to be essential for adequate... Review on novel concepts in wound angiogenesis; although more capillaries are generally considered better, new studies suggest otherwise. All animals heal, and...
SourceID	pubmedcentral proquest pubmed crossref wiley
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	979
SubjectTerms	Angiogenic Proteins - physiology Animals Capillaries - physiology capillary Cicatrix - physiopathology Cicatrix - prevention & control Endothelial Cells - physiology Fetus - physiology Fibrosis Humans inflammation Inflammation - physiopathology Mouth Mucosa - blood supply Mouth Mucosa - injuries Mouth Mucosa - physiology Neovascularization, Physiologic - physiology Pericytes - physiology Prenatal Injuries - physiopathology Regeneration - physiology Review Reviews scar Skin - blood supply Skin - injuries VEGF wound healing Wound Healing - physiology
Title	Angiogenesis and wound repair: when enough is enough
URI	https://onlinelibrary.wiley.com/doi/abs/10.1189%2Fjlb.4MR0316-102R https://www.ncbi.nlm.nih.gov/pubmed/27406995 https://www.proquest.com/docview/1826718849 https://pubmed.ncbi.nlm.nih.gov/PMC6608066
Volume	100
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