Muscle Injury Induces Postoperative Cognitive Dysfunction

Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide va...

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Bibliographic Details
Published in:Scientific reports Vol. 10; no. 1; p. 2768
Main Authors: Guéniot, Lorna, Lepere, Victoria, De Medeiros, Gabriela Ferreira, Danckaert, Anne, Flamant, Patricia, Le Dudal, Marine, Langeron, Olivier, Goossens, Pierre L., Chrétien, Fabrice, Jouvion, Grégory
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 17.02.2020
Nature Publishing Group
Subjects:
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Aging - pathology
Animal cognition
Animal models
Animals
Behavioral plasticity
Brain - pathology
Brain - surgery
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cognitive ability
Cognitive science
Critical care
CX3C Chemokine Receptor 1 - genetics
Cytokines - metabolism
Disease Models, Animal
Experiments
Hippocampus - injuries
Hippocampus - pathology
Hippocampus - surgery
Human health and pathology
Humanities and Social Sciences
Humans
Inflammation
Life Sciences
Locomotion
Long term memory
Male
Memory
Mice
Microglia
Microglia - pathology
Morphology
multidisciplinary
Muscle, Skeletal - injuries
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscle, Skeletal - surgery
Nerve growth factor
Nerve Growth Factor - metabolism
Pathophysiology
Postoperative Cognitive Complications - etiology
Postoperative Cognitive Complications - metabolism
Postoperative Cognitive Complications - pathology
Postoperative Complications - etiology
Postoperative Complications - metabolism
Postoperative Complications - pathology
Regeneration
Science
Science (multidisciplinary)
Skeletal muscle
Surgery
Synaptic plasticity
Young adults
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1 GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1 GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
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PMCID: PMC7026159
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-59639-3