Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities

Prophages are known to encode important virulence factors in the human pathogen Vibrio cholerae . However, little is known about the occurrence and composition of prophage-encoded traits in environmental vibrios. A database of 5,674 prophage-like elements constructed from 1,874 Vibrio genome sequenc...

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Vydáno v:Scientific reports Ročník 8; číslo 1; s. 9973 - 9
Hlavní autoři: Castillo, Daniel, Kauffman, Kathryn, Hussain, Fatima, Kalatzis, Panos, Rørbo, Nanna, Polz, Martin F., Middelboe, Mathias
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 02.07.2018
Nature Publishing Group
Témata:
45
631/326/1321
704/829/826
Antibiotic resistance
CRISPR
Deep sea
Genomes
Humanities and Social Sciences
Hydrothermal vents
Marine fish
multidisciplinary
Pathogens
Prophages
Science
Science (multidisciplinary)
Sediments
Spacer
Species
Strains (organisms)
Toxins
Vibrio
Virulence factors
Zot gene
ISSN:2045-2322, 2045-2322
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Shrnutí:Prophages are known to encode important virulence factors in the human pathogen Vibrio cholerae . However, little is known about the occurrence and composition of prophage-encoded traits in environmental vibrios. A database of 5,674 prophage-like elements constructed from 1,874 Vibrio genome sequences, covering sixty-four species, revealed that prophage-like elements encoding possible properties such as virulence and antibiotic resistance are widely distributed among environmental vibrios, including strains classified as non-pathogenic. Moreover, we found that 45% of Vibrio species harbored a complete prophage-like element belonging to the Inoviridae family, which encode the zonula occludens toxin (Zot) previously described in the V . cholerae . Interestingly, these zot -encoding prophages were found in a variety of Vibrio strains covering both clinical and marine isolates, including strains from deep sea hydrothermal vents and deep subseafloor sediments. In addition, the observation that a spacer from the CRISPR locus in the marine fish pathogen V . anguillarum strain PF7 had 95% sequence identity with a zot gene from the Inoviridae prophage found in V . anguillarum strain PF4, suggests acquired resistance to inoviruses in this species. Altogether, our results contribute to the understanding of the role of prophages as drivers of evolution and virulence in the marine Vibrio bacteria.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-28326-9