The structure, function and evolution of a complete human chromosome 8

The complete assembly of each human chromosome is essential for understanding human biology and evolution 1 , 2 . Here we use complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8. Our assembly resolves the sequence of five previously long-standing gap...

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Vydáno v:	Nature (London) Ročník 593; číslo 7857; s. 101 - 107
Hlavní autoři:	Logsdon, Glennis A., Vollger, Mitchell R., Hsieh, PingHsun, Mao, Yafei, Liskovykh, Mikhail A., Koren, Sergey, Nurk, Sergey, Mercuri, Ludovica, Dishuck, Philip C., Rhie, Arang, de Lima, Leonardo G., Dvorkina, Tatiana, Porubsky, David, Harvey, William T., Mikheenko, Alla, Bzikadze, Andrey V., Kremitzki, Milinn, Graves-Lindsay, Tina A., Jain, Chirag, Hoekzema, Kendra, Murali, Shwetha C., Munson, Katherine M., Baker, Carl, Sorensen, Melanie, Lewis, Alexandra M., Surti, Urvashi, Gerton, Jennifer L., Larionov, Vladimir, Ventura, Mario, Miga, Karen H., Phillippy, Adam M., Eichler, Evan E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 06.05.2021 Nature Publishing Group
Témata:	13/106 14/19 14/32 14/63 38/1 45/15 45/22 45/23 45/29 45/90 631/181/2474 631/208/212 631/208/212/2304 631/337/103/90 Accuracy Animals Arrays Artificial chromosomes Assembly Cell Line Centromere - chemistry Centromere - genetics Centromere - metabolism Centromere protein A Chromosome 8 Chromosomes Chromosomes, Human, Pair 8 - chemistry Chromosomes, Human, Pair 8 - genetics Chromosomes, Human, Pair 8 - physiology Copy number Deoxyribonucleic acid Diploids DNA DNA Methylation DNA, Satellite - genetics Epigenesis, Genetic Evolution Evolution, Molecular Female Gene polymorphism Genes Genomes Genomics Haplotypes Health risks Humanities and Social Sciences Humans Macaca mulatta - genetics Male Minisatellite Repeats - genetics multidisciplinary Mutation Mutation rates Nucleosomes Nucleotide sequence Pan troglodytes - genetics Phylogeny Polymorphism Pongo abelii - genetics Satellite DNA Satellites Science Science (multidisciplinary) Structure-function relationships Telomere - chemistry Telomere - genetics Telomere - metabolism
ISSN:	0028-0836, 1476-4687, 1476-4687
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