FAM13A affects body fat distribution and adipocyte function

Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcuta...

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Veröffentlicht in:	Nature communications Jg. 11; H. 1; S. 1465 - 13
Hauptverfasser:	Fathzadeh, Mohsen, Li, Jiehan, Rao, Abhiram, Cook, Naomi, Chennamsetty, Indumathi, Seldin, Marcus, Zhou, Xiang, Sangwung, Panjamaporn, Gloudemans, Michael J., Keller, Mark, Attie, Allan, Yang, Jing, Wabitsch, Martin, Carcamo-Orive, Ivan, Tada, Yuko, Lusis, Aldons J., Shin, Myung Kyun, Molony, Cliona M., McLaughlin, Tracey, Reaven, Gerald, Montgomery, Stephen B., Reilly, Dermot, Quertermous, Thomas, Ingelsson, Erik, Knowles, Joshua W.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 19.03.2020 Nature Publishing Group Nature Portfolio
Schlagworte:	13/106 13/51 13/89 49/105 49/39 631/208/191/2018 631/208/205 631/443/319/1642 64/60 692/163/2743/393 82/1 96/1 Adipocytes Adipocytes - metabolism Adipogenesis - genetics Adipose tissue Animals Anthropometry Body fat Body Fat Distribution Cell Differentiation - genetics Differentiation Gene Knockdown Techniques Gene mapping Genetic diversity Genetic Loci Genetic variance Genome-wide association studies Genome-Wide Association Study GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism HEK293 Cells High fat diet Hip Humanities and Social Sciences Humans In vivo methods and tests Insulin Insulin resistance Insulin Resistance - genetics Intra-Abdominal Fat - metabolism Loci Male Mapping Metabolism Metabolomics Mice, Inbred C57BL Mice, Knockout multidisciplinary Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Preadipocytes RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Size distribution Subcutaneous Fat - metabolism
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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