A comparative study on the detection and localization of interictal epileptiform discharges in magnetoencephalography using optically pumped magnetometers versus superconducting quantum interference devices

•The applicability of OPM-MEG was assessed in a large cohort of patients with epilepsy.•OPM-MEG had comparable ability in IED detection compared with SQUID-MEG.•OPM-MEG showed significantly higher IED amplitude and SNR than SQUID-MEG.•OPM-MEG exhibited nearly consistent source localization with SQUI...

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Vydáno v:NeuroImage (Orlando, Fla.) Ročník 312; s. 121232
Hlavní autoři: Ren, Jiechuan, Ding, Ming, Peng, Yuming, Sun, Chang, Yang, Chunqing, Zhou, Shuxian, Tian, Jiayin, Wang, Qun, Li, Zhimei
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 15.05.2025
Elsevier Limited
Elsevier
Témata:
Adolescent
Adult
Data collection
Digitization
Electroencephalography
Electron microscopes
Epilepsy
Epilepsy - diagnosis
Epilepsy - physiopathology
Female
Firing pattern
Hospitals
Humans
Interictal epileptiform discharge
Localization
Magnetic fields
Magnetoencephalography
Magnetoencephalography - instrumentation
Magnetoencephalography - methods
Magnetometry - instrumentation
Magnetometry - methods
Male
MEG
OPM
Scalp
Semiotics
Sensors
Signal-To-Noise Ratio
Software
SQUID
Statistical analysis
Tomography
Young Adult
Beijing China
China
Interictal epileptiform discharge
SQUID
Epilepsy
SNR
IED
OPM
MSR
MEG
ISSN:1053-8119, 1095-9572, 1095-9572
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Shrnutí:•The applicability of OPM-MEG was assessed in a large cohort of patients with epilepsy.•OPM-MEG had comparable ability in IED detection compared with SQUID-MEG.•OPM-MEG showed significantly higher IED amplitude and SNR than SQUID-MEG.•OPM-MEG exhibited nearly consistent source localization with SQUID-MEG. Superconducting quantum interference device (SQUID)-based magnetoencephalography (MEG) holds substantial clinical value in epilepsy examination but is limited by the high costs. The optically pumped magnetometer (OPM)-based MEG appears promising in overcoming these limitations. This study aims to explore the consistency of interictal epileptiform discharge (IED) detection and source localization between OPM-MEG and SQUID-MEG in a large cohort of patients with epilepsy. Patients with epilepsy underwent SQUID-MEG and 128-channel whole-scalp OPM-MEG examinations. IED detection, amplitude, signal-to-noise ratio (SNR), sensor-scalp distance, and source localization results were compared between OPM-MEG and SQUID-MEG through statistical analysis. The cohort comprised 46 patients with epilepsy (mean age, 23.7 ± 8.7 [SD] years; 29 male). McNemar χ2 test indicated no significant difference for IED detection between two systems. OPM-MEG achieved a detection accuracy of 91.3 % compared with SQUID-MEG; a Gwet's first-order agreement coefficient (AC1) of 0.892 suggested good consistency. Among 39 patients with IEDs detected by both systems, OPM-MEG demonstrated closer sensor-scalp distance (p < 0.001), higher IED amplitude (p < 0.001) and SNR (p = 0.003) compared with SQUID-MEG. At the sublobar level, OPM-MEG and SQUID-MEG exhibited nearly consistent source localization results. Among 24 patients with single dipole clusters, the average centroid distance between dipole clusters of OPM-MEG and SQUID-MEG was 12.16 ± 5.90 mm. This real-world study demonstrated that OPM-MEG had comparable applicability in IED detection and source localization, compared with SQUID-MEG. Additionally, OPM-MEG performed better in terms of IED amplitude and SNR. Lower costs and user-friendly features highlight the clinical potential of OPM-MEG in epilepsy assessments.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2025.121232