Exploring the potential of stratum corneum biomarkers for assessing psychological distress in health care workers: An observational pilot study
Backgrounds The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs). Aim The aim of this study is to explore SC biomarkers of immune and...
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John Wiley & Sons, Inc
01.01.2024
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| Abstract | Backgrounds
The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs).
Aim
The aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs.
Methods
Twenty‐five female HCWs and 25 non‐HCWs participated. SC samples were collected using adhesive tapes at baseline and 3−5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann‐Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon‐signed rank.
Results
Fourteen SC biomarkers were identified. We found correlations between general stress and “IL18” (r = 0.55) physical stress and “IL1b” (r = 0.36) and cognitive stress and “MIP3a” (r = 0.38) at baseline and general stress and cortisol (r = −0.49), physical stress and cortisol (r = −0.60) and cortisone (r = −0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for “MIP3a” at baseline. Differences in the biomarker levels between two time points were found for “TARC,” “VEGFA,” “ILRA,” “IL1RA/IL1a,” “NMF,” and “DHEA.”
Conclusion
The SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well‐known stress hormones, cortisol and cortisone. |
|---|---|
| AbstractList | Abstract Backgrounds The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs). Aim The aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs. Methods Twenty‐five female HCWs and 25 non‐HCWs participated. SC samples were collected using adhesive tapes at baseline and 3−5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann‐Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon‐signed rank. Results Fourteen SC biomarkers were identified. We found correlations between general stress and “IL18” (r = 0.55) physical stress and “IL1b” (r = 0.36) and cognitive stress and “MIP3a” (r = 0.38) at baseline and general stress and cortisol (r = −0.49), physical stress and cortisol (r = −0.60) and cortisone (r = −0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for “MIP3a” at baseline. Differences in the biomarker levels between two time points were found for “TARC,” “VEGFA,” “ILRA,” “IL1RA/IL1a,” “NMF,” and “DHEA.” Conclusion The SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well‐known stress hormones, cortisol and cortisone. The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs). The aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs. Twenty-five female HCWs and 25 non-HCWs participated. SC samples were collected using adhesive tapes at baseline and 3-5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann-Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon-signed rank. Fourteen SC biomarkers were identified. We found correlations between general stress and "IL18" ( = 0.55) physical stress and "IL1b" ( = 0.36) and cognitive stress and "MIP3a" ( = 0.38) at baseline and general stress and cortisol ( = -0.49), physical stress and cortisol ( = -0.60) and cortisone ( = -0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for "MIP3a" at baseline. Differences in the biomarker levels between two time points were found for "TARC," "VEGFA," "ILRA," "IL1RA/IL1a," "NMF," and "DHEA." The SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well-known stress hormones, cortisol and cortisone. Backgrounds The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs). Aim The aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs. Methods Twenty‐five female HCWs and 25 non‐HCWs participated. SC samples were collected using adhesive tapes at baseline and 3−5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann‐Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon‐signed rank. Results Fourteen SC biomarkers were identified. We found correlations between general stress and “IL18” (r = 0.55) physical stress and “IL1b” (r = 0.36) and cognitive stress and “MIP3a” (r = 0.38) at baseline and general stress and cortisol (r = −0.49), physical stress and cortisol (r = −0.60) and cortisone (r = −0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for “MIP3a” at baseline. Differences in the biomarker levels between two time points were found for “TARC,” “VEGFA,” “ILRA,” “IL1RA/IL1a,” “NMF,” and “DHEA.” Conclusion The SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well‐known stress hormones, cortisol and cortisone. The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs).BackgroundsThe detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs).The aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs.AimThe aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs.Twenty-five female HCWs and 25 non-HCWs participated. SC samples were collected using adhesive tapes at baseline and 3-5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann-Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon-signed rank.MethodsTwenty-five female HCWs and 25 non-HCWs participated. SC samples were collected using adhesive tapes at baseline and 3-5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann-Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon-signed rank.Fourteen SC biomarkers were identified. We found correlations between general stress and "IL18" (r = 0.55) physical stress and "IL1b" (r = 0.36) and cognitive stress and "MIP3a" (r = 0.38) at baseline and general stress and cortisol (r = -0.49), physical stress and cortisol (r = -0.60) and cortisone (r = -0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for "MIP3a" at baseline. Differences in the biomarker levels between two time points were found for "TARC," "VEGFA," "ILRA," "IL1RA/IL1a," "NMF," and "DHEA."ResultsFourteen SC biomarkers were identified. We found correlations between general stress and "IL18" (r = 0.55) physical stress and "IL1b" (r = 0.36) and cognitive stress and "MIP3a" (r = 0.38) at baseline and general stress and cortisol (r = -0.49), physical stress and cortisol (r = -0.60) and cortisone (r = -0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for "MIP3a" at baseline. Differences in the biomarker levels between two time points were found for "TARC," "VEGFA," "ILRA," "IL1RA/IL1a," "NMF," and "DHEA."The SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well-known stress hormones, cortisol and cortisone.ConclusionThe SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well-known stress hormones, cortisol and cortisone. BackgroundsThe detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs).AimThe aim of this study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs.MethodsTwenty-five female HCWs and 25 non-HCWs participated. SC samples were collected using adhesive tapes at baseline and 3−5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann-Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon-signed rank.ResultsFourteen SC biomarkers were identified. We found correlations between general stress and “IL18” (r = 0.55) physical stress and “IL1b” (r = 0.36) and cognitive stress and “MIP3a” (r = 0.38) at baseline and general stress and cortisol (r = −0.49), physical stress and cortisol (r = −0.60) and cortisone (r = −0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for “MIP3a” at baseline. Differences in the biomarker levels between two time points were found for “TARC,” “VEGFA,” “ILRA,” “IL1RA/IL1a,” “NMF,” and “DHEA.”ConclusionThe SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well-known stress hormones, cortisol and cortisone. |
| Author | Kirschbaum, Clemens Peremin, Ines Kezic, Sanja Schaafsma, Frederieke G. Molen, Henk F. Jakasa, Ivone Emal, Lima M. Tamminga, Sietske J. |
| AuthorAffiliation | 1 Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam Amsterdam Noord‐Holland Netherlands 3 Department of Psychology Technische Universität Dresden Dresden Germany 2 Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology University of Zagreb Zagreb Croatia |
| AuthorAffiliation_xml | – name: 1 Department of Public and Occupational health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam Amsterdam Noord‐Holland Netherlands – name: 3 Department of Psychology Technische Universität Dresden Dresden Germany – name: 2 Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology University of Zagreb Zagreb Croatia |
| Author_xml | – sequence: 1 givenname: Lima M. orcidid: 0000-0003-4233-2639 surname: Emal fullname: Emal, Lima M. email: Lima.emal@amsterdamumc.nl organization: University of Amsterdam – sequence: 2 givenname: Sietske J. surname: Tamminga fullname: Tamminga, Sietske J. organization: University of Amsterdam – sequence: 3 givenname: Frederieke G. surname: Schaafsma fullname: Schaafsma, Frederieke G. organization: University of Amsterdam – sequence: 4 givenname: Ivone surname: Jakasa fullname: Jakasa, Ivone organization: University of Zagreb – sequence: 5 givenname: Ines surname: Peremin fullname: Peremin, Ines organization: University of Zagreb – sequence: 6 givenname: Clemens surname: Kirschbaum fullname: Kirschbaum, Clemens organization: Technische Universität Dresden – sequence: 7 givenname: Henk F. surname: Molen fullname: Molen, Henk F. email: h.f.vandermolen@amsterdamumc.nl organization: University of Amsterdam – sequence: 8 givenname: Sanja surname: Kezic fullname: Kezic, Sanja organization: University of Amsterdam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38186941$$D View this record in MEDLINE/PubMed |
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The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and... The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of... BackgroundsThe detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and... Abstract Backgrounds The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress... |
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| SubjectTerms | Biomarkers Cytokines epidermis health personnel Homeostasis Hormones Immune response Immunology Medical personnel occupational health Original Research Pilot projects psychological Questionnaires Skin stress |
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| Title | Exploring the potential of stratum corneum biomarkers for assessing psychological distress in health care workers: An observational pilot study |
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