Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients with CAP renders it difficult to distinguish immune f...

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Bibliographic Details
Published in:	eLife Vol. 10
Main Authors:	Schuurman, Alex R, Reijnders, Tom DY, Saris, Anno, Ramirez Moral, Ivan, Schinkel, Michiel, de Brabander, Justin, van Linge, Christine, Vermeulen, Louis, Scicluna, Brendon P, Wiersinga, W Joost, Vieira Braga, Felipe A, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 23.08.2021 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Adult Aged Analysis Antibodies Biological response modifiers CD8 antigen Cell cycle Community-Acquired Infections - immunology Coronaviruses COVID-19 COVID-19 - immunology Cytotoxicity Ethylenediaminetetraacetic acid Female Genomics Health aspects Humans Immune response Immunology and Inflammation Infections Influenza Influenza A Influenza, Human - immunology Interferon Killer cells Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Male Microbiology and Infectious Disease Middle Aged Monocytes Natural killer cells PBMC Peripheral blood mononuclear cells Pneumonia Pneumonia - immunology Pneumonia - virology Proteomics Proteomics - methods SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Single-Cell Analysis Tagging Transcription Transcriptome Transcriptomics Canada Netherlands COVID-19 Pneumonia infectious disease inflammation microbiology PBMC human immunology
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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