Vibrational spectroscopies for the analysis of cutaneous permeation: experimental limiting factors identified in the case of caffeine penetration

Caffeine is utilised as a reference for permeation studies in dermatology and cosmetology. The present work aimed to monitor the permeation of a caffeine solution through the skin. For this purpose, Raman and infrared studies were performed. Raman microspectroscopy permitted a dynamic follow-up of t...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry Vol. 405; no. 4; pp. 1325 - 1332
Main Authors: Tfaili, Sana, Gobinet, Cyril, Josse, Gwendal, Angiboust, Jean-François, Baillet, Arlette, Manfait, Michel, Piot, Olivier
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01.02.2013
Springer
Springer Nature B.V
Springer Verlag
Subjects:
Abdomen
Administration, Cutaneous
Analytical Chemistry
Biochemistry
Caffeine
Caffeine - administration & dosage
Caffeine - analysis
Caffeine - metabolism
Characterization and Evaluation of Materials
Chemical properties
Chemistry
Chemistry and Materials Science
Composition
Constraining
Cosmetics
Cosmetology
Dermatology
Food Science
Fourier transforms
Humans
Hydration
Identification and classification
Infrared
Kinetics
Laboratory Medicine
Methods
Monitoring/Environmental Analysis
Monitors
Original Paper
Penetration
Permeability
Permeation
Pharmacy
Physiological aspects
Raman spectroscopy
Skin
Skin - chemistry
Skin - metabolism
Spectroscopy
Spectroscopy, Near-Infrared - methods
Spectrum analysis
Spectrum Analysis, Raman - methods
Tracking
Vibration
France
United Kingdom > UK
Skin
Raman spectroscopy
Drug screening
IR spectroscopy
Chemometrics
ISSN:1618-2642, 1618-2650, 1618-2650
Online Access:Get full text
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Summary:Caffeine is utilised as a reference for permeation studies in dermatology and cosmetology. The present work aimed to monitor the permeation of a caffeine solution through the skin. For this purpose, Raman and infrared studies were performed. Raman microspectroscopy permitted a dynamic follow-up of the caffeine diffusion. In complementary, infrared microimaging provided information of the caffeine localization in the skin by applying multivariate statistical processing on skin tissue sections. Herein, we prove the possibility of tracking low concentrations of caffeine through the skin and we highlight some experimental limitations of vibrational spectroscopies.
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ISSN:1618-2642
1618-2650
1618-2650
DOI:10.1007/s00216-012-6512-7