Antimycobacterial Activity of Solid Lipid Microparticles Loaded with Ursolic Acid and Oleanolic Acid: In Vitro, In Vivo, and Toxicity Assessments

Ursolic acid (UA) and oleanolic acid (OA) are hydrophobic triterpenoid isomers with demonstrated anti-mycobacterial (Mtb) and immune-regulatory properties, although their poor solubility limits clinical use. We report the development of solid lipid microparticles (SLMs) as delivery vehicles for UA a...

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Bibliographic Details
Published in:	Microorganisms (Basel) Vol. 12; no. 11; p. 2140
Main Authors:	Saini, Vinay, Mata Espinosa, Dulce, Pandey, Alok, Dighe, Vikas, Barrios Payán, Jorge, Prasad Myneedu, Vithal, Valdez Zarate, Ivan, Rajani, Dhanji P., Anande, Lalit D., Hernandez Pando, Rogelio, Srivastava, Rohit
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.11.2024 MDPI
Subjects:	Acids Acquired immune deficiency syndrome Acute toxicity AIDS Alveoli Animal models anti-tuberculosis activity Antibiotics Bacteria Bioavailability Biocompatibility Diabetes Drug resistance Herbal medicine HIV Homogenization Human immunodeficiency virus Hydrophobicity in vivo acute toxicity In vivo methods and tests Inhalers Isomers Lipids Lungs Macrophages Microparticles Minimum inhibitory concentration Multidrug resistance Natural products Oleanolic acid Polyvinyl alcohol solid lipid microparticles Terpenes Toxicity Tuberculosis Ursolic acid United Kingdom Bolivia United States New Jersey Missouri India St Louis Missouri United States > US anti-tuberculosis activity solid lipid microparticles oleanolic acid in vivo acute toxicity tuberculosis ursolic acid
ISSN:	2076-2607, 2076-2607
Online Access:	Get full text
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