Frontal tDCS modulates orbitofrontal reality filtering

•Reality filtering is necessary to keep thought and behavior in phase with reality.•We tested the influence of orbitofrontal tDCS on reality filtering.•Modeling predicted that tDCS with a frontal electrode can reach the posterior OFC.•Cathodal tDCS of the orbitofrontal cortex specifically impaired r...

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Veröffentlicht in:Neuroscience Jg. 265; S. 21 - 27
Hauptverfasser: Manuel, A.L., David, A.W., Bikson, M., Schnider, A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Amsterdam Elsevier Ltd 18.04.2014
Elsevier
Schlagworte:
Adolescent
Adult
Biological and medical sciences
confabulations
continuous recognition task
Electric Stimulation
extinction
Female
Frontal Lobe - physiology
Fundamental and applied biological sciences. Psychology
Humans
Male
Memory - physiology
Neurology
orbitofrontal cortex
Prefrontal Cortex - physiology
Recognition (Psychology) - physiology
tDCS
Vertebrates: nervous system and sense organs
Young Adult
SD
extinction
DLPFC
ANOVA
tDCS
continuous recognition task
orbitofrontal cortex
OFC
FE
finite element
dorsolateral prefrontal cortex
transcranial direct current stimulation
confabulations
analysis of variance
standard deviation
Orbitofrontal cortex
Central nervous system
Encephalon
ISSN:0306-4522, 1873-7544, 1873-7544
Online-Zugang:Volltext
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Zusammenfassung:•Reality filtering is necessary to keep thought and behavior in phase with reality.•We tested the influence of orbitofrontal tDCS on reality filtering.•Modeling predicted that tDCS with a frontal electrode can reach the posterior OFC.•Cathodal tDCS of the orbitofrontal cortex specifically impaired reality filtering.•Orbitofrontal reality filtering can be influenced through stimulation. Orbitofrontal reality filtering denotes a memory control mechanism necessary to keep thought and behavior in phase with reality. Its failure induces reality confusion as evident in confabulation and disorientation. In the present study, we explored the influence of orbitofrontal transcranial direct current stimulation (tDCS) on reality filtering. Twenty healthy human subjects made a reality filtering task, while receiving cathodal, anodal, or sham stimulation over the frontal pole in three sessions separated by at least 1week. Computational models predicted that this montage can produce polarity-specific current flow across the posterior medial orbitofrontal cortex (OFC). In agreement with our hypothesis, we found that cathodal tDCS over the frontal pole specifically impaired reality filtering in comparison to anodal and sham stimulation. This study shows that reality filtering, an orbitofrontal function, can be modulated with tDCS.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
1873-7544
DOI:10.1016/j.neuroscience.2014.01.052