Feedback inhibition underlies new computational functions of cerebellar interneurons

The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in th...

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Bibliographic Details
Published in:	eLife Vol. 11
Main Authors:	Halverson, Hunter E, Kim, Jinsook, Khilkevich, Andrei, Mauk, Michael D, Augustine, George J
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 08.12.2022 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Analysis Biological research Biology, Experimental Brain slice preparation cerebellar learning Cerebellum Cerebellum - physiology Computational neuroscience disinhibition Eyelid Eyelids Feedback feedback circuit Feedback inhibition Genetics Information processing Information storage Interneurons Interneurons - physiology Mathematical models molecular layer interneurons Neural recording Neurons Neuroscience Optics Purkinje cells Purkinje Cells - physiology Transgenic animals United Kingdom molecular layer interneurons mouse neuroscience feedback circuit rabbit cerebellar learning disinhibition
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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