Nanoparticle-Based Drug Delivery for Vascular Applications

Nanoparticle (NP)-based drug delivery systems have received widespread attention due to the excellent physicochemical properties of nanomaterials. Different types of NPs such as lipid NPs, poly(lactic-co-glycolic) acid (PLGA) NPs, inorganic NPs (e.g., iron oxide and Au), carbon NPs (graphene and car...

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Vydané v:Bioengineering (Basel) Ročník 11; číslo 12; s. 1222
Hlavní autori: Naskar, Atanu, Kilari, Sreenivasulu, Baranwal, Gaurav, Kane, Jamie, Misra, Sanjay
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.12.2024
MDPI
Predmet:
Bioavailability
Biocompatibility
biomedical applications
Blood vessels
Carbon
Cell surface
Drug delivery
Drug delivery systems
Drugs
Endothelium
FDA approval
Ferric oxide
Graphene
Iron oxides
Lipids
Medical research
Membranes
Nanomaterials
nanoparticle
Nanoparticles
Nanotechnology
Permeability
Physicochemical properties
Polylactide-co-glycolide
Proteins
Review
Toxicity
vascular applications
Vehicles
vascular applications
endothelium
nanoparticle
drug delivery
biomedical applications
ISSN:2306-5354, 2306-5354
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Popis
Shrnutí:Nanoparticle (NP)-based drug delivery systems have received widespread attention due to the excellent physicochemical properties of nanomaterials. Different types of NPs such as lipid NPs, poly(lactic-co-glycolic) acid (PLGA) NPs, inorganic NPs (e.g., iron oxide and Au), carbon NPs (graphene and carbon nanodots), 2D nanomaterials, and biomimetic NPs have found favor as drug delivery vehicles. In this review, we discuss the different types of customized NPs for intravascular drug delivery, nanoparticle behaviors (margination, adhesion, and endothelium uptake) in blood vessels, and nanomaterial compatibility for successful drug delivery. Additionally, cell surface protein targets play an important role in targeted drug delivery, and various vascular drug delivery studies using nanoparticles conjugated to these proteins are reviewed. Finally, limitations, challenges, and potential solutions for translational research regarding NP-based vascular drug delivery are discussed.
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ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering11121222