Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy

Background Enhancer of zeste 2 (EZH2) promotes prostate cancer progression. We hypothesized that increased EZH2 expression is associated with postradiotherapy metastatic disease recurrence, and may promote radioresistance. Methods EZH2 expression was investigated using immunohistochemistry in diagno...

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Bibliographic Details
Published in:	The Prostate Vol. 79; no. 10; pp. 1079 - 1089
Main Authors:	Wu, Xiaoning, Scott, Helen, Carlsson, Sigrid V., Sjoberg, Daniel D., Cerundolo, Lucia, Lilja, Hans, Prevo, Remko, Rieunier, Guillaume, Macaulay, Valentine, Higgins, Geoffrey S., Verrill, Clare L., Lamb, Alastair D., Cunliffe, Vincent T., Bountra, Chas, Hamdy, Freddie C., Bryant, Richard J.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.07.2019 John Wiley and Sons Inc
Subjects:	androgen biochemical failure Biopsy Bone Neoplasms - metabolism Bone Neoplasms - secondary Cancer and Oncology Cancer och onkologi Cell Line, Tumor Clinical Medicine Colonies Disease Progression DNA-damage Endocrinology & Metabolism enhancer of zeste 2 Enhancer of Zeste Homolog 2 Protein - metabolism group protein ezh2 Histone H3 histone methyltransferase activity Humans Immunohistochemistry Klinisk medicin Lysine Male Medical and Health Sciences Medicin och hälsovetenskap Metastases Metastasis Methylation Multivariate analysis Neoplasm Grading Nephrology Njurmedicin Original proliferation Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Radiation therapy Radioresistance Radiosensitivity radiotherapy risk Soft Tissue Neoplasms - metabolism Soft Tissue Neoplasms - secondary Statistical analysis suppression Urology & Nephrology valproic acid radiotherapy prostate cancer enhancer of zeste 2
ISSN:	0270-4137, 1097-0045, 1097-0045
Online Access:	Get full text
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