Patterns of functional connectivity in an aging population: The Rotterdam Study

Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration. However, brain structure and func...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 189; pp. 432 - 444
Main Authors: Zonneveld, Hazel I., Pruim, Raimon HR, Bos, Daniel, Vrooman, Henri A., Muetzel, Ryan L., Hofman, Albert, Rombouts, Serge ARB, van der Lugt, Aad, Niessen, Wiro J., Ikram, M. Arfan, Vernooij, Meike W.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.04.2019
Elsevier Limited
Subjects:
Age Factors
Aged
Aged, 80 and over
Aging
Aging - physiology
Alzheimer's disease
Blood pressure
Brain - diagnostic imaging
Brain - physiology
Brain networks
Brain research
Cohort Studies
Connectome - methods
Dementia
Epidemiology
Female
Functional anatomy
Functional connectivity
Humans
Magnetic Resonance Imaging
Male
Middle age
Middle Aged
Nerve Net - diagnostic imaging
Nerve Net - physiology
Netherlands
Neural networks
Neurodegeneration
Neurodegenerative diseases
Population
Population studies
Population-based
Population-based studies
R&D
Research & development
Resting-state functional MRI
Sensorimotor system
Structure-function relationships
Studies
Netherlands
Functional connectivity
Aging
Population-based
Resting-state functional MRI
Brain networks
Epidemiology
ISSN:1053-8119, 1095-9572, 1095-9572
Online Access:Get full text
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Summary:Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration. However, brain structure and function are also affected by ‘normal’ brain ageing. More information is needed on how functional connectivity relates to aging, particularly in the absence of overt neurodegenerative disease. We investigated the association of age with resting-state functional connectivity in 2878 non-demented persons between 50 and 95 years of age (54.1% women) from the population-based Rotterdam Study. We obtained nine well-known resting state networks using data-driven methodology. Within the anterior default mode network, ventral attention network, and sensorimotor network, functional connectivity was significantly lower with older age. In contrast, functional connectivity was higher with older age within the visual network. Between resting state networks, we found patterns of both increases and decreases in connectivity in approximate equal proportions. Our results reinforce the notion that the aging brain undergoes a reorganization process, and serves as a solid basis for exploring functional connectivity as a preclinical marker of neurodegenerative disease. •The aging brain undergoes a complex functional reorganization process.•Age is related to decreases in within-network functional connectivity and to widespread increases and decreases in (anti-)correlations between different networks.•This study forms a basis for exploring functional connectivity as a preclinical marker of neurodegenerative disease.
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2019.01.041