Plasma mitochondrial DNA and metabolomic alterations in severe critical illness

Background Cell-free plasma mitochondrial DNA (mtDNA) levels are associated with endothelial dysfunction and differential outcomes in critical illness. A substantial alteration in metabolic homeostasis is commonly observed in severe critical illness. We hypothesized that metabolic profiles significa...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 22; no. 1; pp. 360 - 9
Main Authors:	Johansson, Pär I., Nakahira, Kiichi, Rogers, Angela J., McGeachie, Michael J., Baron, Rebecca M., Fredenburgh, Laura E., Harrington, John, Choi, Augustine M. K., Christopher, Kenneth B.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.12.2018 BioMed Central Ltd BMC
Subjects:	Acylcarnitine Adult Aged Analysis Boston Critical Care Medicine Critical illness Critical Illness - therapy Critically ill persons Discriminant Analysis DNA, Mitochondrial - adverse effects DNA, Mitochondrial - pharmacology DNA, Mitochondrial - therapeutic use Emergency Medicine Emolument Endothelial Cells - drug effects Endothelium Female Health aspects Homeostasis Humans Intensive Male Medicine Medicine & Public Health Metabolite Metabolomics Metabolomics - methods Middle Aged Mitochondrial DNA Registries - statistics & numerical data Boston Metabolomics Critical illness Metabolite Homeostasis Acylcarnitine Mitochondrial DNA Glycerophosphocholine
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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