Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality

Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 348; no. 6235; pp. 694 - 699
Main Authors:	Mina, Michael J, Metcalf, C Jessica E, de Swart, Rik L, Osterhaus, A D M E, Grenfell, Bryan T
Format:	Journal Article
Language:	English
Published:	United States 08.05.2015
Subjects:	B-Lymphocytes - immunology Child Child Mortality Child, Preschool England - epidemiology Female Humans Immunologic Memory Immunomodulation Incidence Lymphocyte Depletion Male Measles - epidemiology Measles - immunology Measles - prevention & control Measles Vaccine - administration & dosage Measles Vaccine - immunology Opportunistic Infections - immunology Opportunistic Infections - mortality Opportunistic Infections - prevention & control T-Lymphocytes - immunology Time Factors United States - epidemiology Vaccination Wales - epidemiology England United States Wales
ISSN:	1095-9203
Online Access:	Get more information
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