Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy

Spinal cord atrophy measurements obtained from structural magnetic resonance imaging (MRI) are associated with disability in many neurological diseases and serve as in vivo biomarkers of neurodegeneration. Longitudinal spinal cord atrophy rate is commonly determined from the numerical difference bet...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Jg. 209; S. 116489
Hauptverfasser: Prados, Ferran, Moccia, Marcello, Johnson, Aubrey, Yiannakas, Marios, Grussu, Francesco, Cardoso, Manuel Jorge, Ciccarelli, Olga, Ourselin, Sebastien, Barkhof, Frederik, Wheeler-Kingshott, Claudia
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.04.2020
Elsevier Limited
Elsevier
Schlagworte:
Adult
Algorithms
Atrophy
Atrophy - pathology
Bias
Clinical trials
Disease
Disease Progression
Double-Blind Method
Female
Humans
Image Interpretation, Computer-Assisted - methods
Image Interpretation, Computer-Assisted - standards
Longitudinal Studies
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - standards
Male
Methods
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Neurodegeneration
Neuroimaging - methods
Neuroimaging - standards
Neurological diseases
Noise
Pipelines
Registration
Scanners
Segmentation
Software
Spinal cord
Spinal Cord - diagnostic imaging
Spinal Cord - pathology
ISSN:1053-8119, 1095-9572, 1095-9572
Online-Zugang:Volltext
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Zusammenfassung:Spinal cord atrophy measurements obtained from structural magnetic resonance imaging (MRI) are associated with disability in many neurological diseases and serve as in vivo biomarkers of neurodegeneration. Longitudinal spinal cord atrophy rate is commonly determined from the numerical difference between two volumes (based on 3D surface fitting) or two cross-sectional areas (CSA, based on 2D edge detection) obtained at different time-points. Being an indirect measure, atrophy rates are susceptible to variable segmentation errors at the edge of the spinal cord. To overcome those limitations, we developed a new registration-based pipeline that measures atrophy rates directly. We based our approach on the generalised boundary shift integral (GBSI) method, which registers 2 scans and uses a probabilistic XOR mask over the edge of the spinal cord, thereby measuring atrophy more accurately than segmentation-based techniques. Using a large cohort of longitudinal spinal cord images (610 subjects with multiple sclerosis from a multi-centre trial and 52 healthy controls), we demonstrated that GBSI is a sensitive, quantitative and objective measure of longitudinal spinal cord volume change. The GBSI pipeline is repeatable, reproducible, and provides more precise measurements of longitudinal spinal cord atrophy than segmentation-based methods in longitudinal spinal cord atrophy studies. •GBSI is a registration-based pipeline that measures longitudinal spinal cord atrophy.•GBSI is a sensitive and objective measure of longitudinal spinal cord volume change.•A new promising method for computing spinal cord atrophy in clinical trials.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2019.116489