A genetically encoded sensor for measuring serotonin dynamics

Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the release of 5-HT, we developed a genetically encoded G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB 5-HT ) sensor with high sensitivity, hi...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 24; no. 5; pp. 746 - 752
Main Authors:	Wan, Jinxia, Peng, Wanling, Li, Xuelin, Qian, Tongrui, Song, Kun, Zeng, Jianzhi, Deng, Fei, Hao, Suyu, Feng, Jiesi, Zhang, Peng, Zhang, Yajun, Zou, Jing, Pan, Sunlei, Shin, Mimi, Venton, B. Jill, Zhu, J. Julius, Jing, Miao, Xu, Min, Li, Yulong
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2021 Nature Publishing Group
Subjects:	631/1647/1888 631/378 631/443 96/35 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Biosensors Brain research Female G protein-coupled receptors Genetic code Genetic engineering Health aspects HEK293 Cells Humans Male Methods Mice Molecular dynamics Monoamines Neurobiology Neurons - metabolism Neurosciences Neurotransmitters Phylogeny Physiological aspects Rats Receptors, G-Protein-Coupled - metabolism Selectivity Sensitivity Sensors Serotonergic Neurons - metabolism Serotonin Serotonin - metabolism Signal Transduction - physiology technical-report China
ISSN:	1097-6256, 1546-1726, 1546-1726
Online Access:	Get full text
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