Mutant Cohesin in Premature Ovarian Failure

Few genes have been implicated in sporadic premature ovarian failure. This study implicates STAG3, which encodes a cohesin, a protein that mediates chromosome pairing during meiosis. Premature ovarian failure, the end point of primary ovarian insufficiency, affects approximately 1% of women worldwid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine Jg. 370; H. 10; S. 943 - 949
Hauptverfasser:	Caburet, Sandrine, Arboleda, Valerie A, Llano, Elena, Overbeek, Paul A, Barbero, Jose Luis, Oka, Kazuhiro, Harrison, Wilbur, Vaiman, Daniel, Ben-Neriah, Ziva, García-Tuñón, Ignacio, Fellous, Marc, Pendás, Alberto M, Veitia, Reiner A, Vilain, Eric
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Waltham, MA Massachusetts Medical Society 06.03.2014
Schriftenreihe:	Brief Report
Schlagworte:	Animals Biochemistry, Molecular Biology Biological and medical sciences Cell Cycle Proteins Cell Cycle Proteins - genetics Chromosomal Proteins, Non-Histone Chromosomal Proteins, Non-Histone - genetics Chromosome 7 Chromosome deletion Cohesin Cohesins Disease Models, Animal Diseases of mother, fetus and pregnancy Female Fetuses Frameshift mutation Gene deletion General aspects Genetics Gynecology and obstetrics Gynecology. Andrology. Obstetrics Human health and pathology Humans Infertility Infertility, Female Infertility, Female - genetics Life Sciences Medical sciences Meiosis Mice Mutation Nuclear Proteins Nuclear Proteins - genetics Oocytes Pedigree Pregnancy. Fetus. Placenta Primary Ovarian Insufficiency Primary Ovarian Insufficiency - genetics Prophase Reproductive status Reproductive system Womens health Los Angeles California United States > US Endocrinopathy Medicine Premature Ovarian diseases Ovarian failure Female genital diseases
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!