Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Between 10 and 20 million people worldwide are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). Despite causing life-threatening pathologies there is no therapeutic regimen for this deltaretrovirus. Here, we screened a library of integrase strand transfer inhibitor (INSTI) candidat...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 4996 - 10
Main Authors:	Barski, Michal S., Vanzo, Teresa, Zhao, Xue Zhi, Smith, Steven J., Ballandras-Colas, Allison, Cronin, Nora B., Pye, Valerie E., Hughes, Stephen H., Burke, Terrence R., Cherepanov, Peter, Maertens, Goedele N.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.08.2021 Nature Publishing Group Nature Portfolio
Subjects:	101/28 13/106 631/326/596/1787 631/535/1258/1259 82/16 82/29 82/83 Amides Antiretroviral drugs Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding Catalytic Domain Cryoelectron Microscopy Deltaretrovirus Disease prevention Drug Resistance, Viral - drug effects Electron microscopy Heterocyclic Compounds, 3-Ring HIV HIV Integrase - drug effects HIV-1 HTLV-I Infections - drug therapy Human immunodeficiency virus Human T-lymphotropic virus 1 - drug effects Human T-lymphotropic virus 1 - genetics Humanities and Social Sciences Humans Infections Inhibitors Integrase Ion pairs Life Sciences Lymphocytes T Magnesium multidisciplinary Naphthyridines - pharmacology Piperazines Prophylaxis Pyridones Recombinant Proteins Science Science (multidisciplinary) Structural analysis Viruses
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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