Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa

Thirty-eight patients from 37 families with retinitis pigmentosa (RP) underwent macular 6 × 6-mm swept-source optical coherence tomography angiography (SS-OCTA) and 30° near-infrared fundus autofluorescence (NIR-FAF) acquisitions in one eye. Superficial vascular complex (SVC), deep capillary complex...

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Veröffentlicht in:Scientific reports Jg. 11; H. 1; S. 3180 - 12
Hauptverfasser: Nassisi, Marco, Lavia, Carlo, Mohand-Said, Saddek, Smirnov, Vasily, Antonio, Aline, Condroyer, Christel, Sancho, Serge, Varin, Juliette, Gaudric, Alain, Zeitz, Christina, Sahel, José-Alain, Audo, Isabelle
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 04.02.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
692/699/3161/3165
692/699/3161/3175
Angiography
Atrophy
Eye
Humanities and Social Sciences
I.R. radiation
Life Sciences
Medical imaging
multidisciplinary
Retina
Retinal degeneration
Retinitis
Retinitis pigmentosa
Science
Science (multidisciplinary)
Tomography
ISSN:2045-2322, 2045-2322
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Zusammenfassung:Thirty-eight patients from 37 families with retinitis pigmentosa (RP) underwent macular 6 × 6-mm swept-source optical coherence tomography angiography (SS-OCTA) and 30° near-infrared fundus autofluorescence (NIR-FAF) acquisitions in one eye. Superficial vascular complex (SVC), deep capillary complex (DCC) and choriocapillaris (CC) angiograms were registered with NIR-FAF acquisitions to comparatively assess subjects with and without central area of preserved NIR-FAF (APA). On the subset of patients showing an APA, the vessel densities for SVC and DCC and flow deficits for CC were assessed in three directions (superior, inferior and temporal) from the fovea and compared to healthy 1:1 age-matched controls. Nine patients with no APA had evidence of severe central OCTA alterations at all levels, especially in the DCC. In the other 29 subjects presenting APA, all OCTA parameters were similar to healthy eyes within the APA, where the retina preserves its structural integrity. Outside the APA, both the DCC and CC were significantly reduced in all directions. These alterations are probably related to the outer retinal atrophy outside the APA. Comparing OCTA to other imaging modalities is helpful to determine the potential interest of OCTA findings as an outcome measure for disease status and progression.
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PMCID: PMC7862375
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-82757-5