Multiomics Analysis Reveals Significant Disparities in the Oral Microbiota and Metabolites Between Pregnant Women with and without Periodontitis

Our study investigated the disparities and correlations between oral microbiota and metabolites in pregnant patients with and without periodontitis. Subgingival plaque samples from all subjects were collected for shotgun metagenomic sequencing and broad-target metabolomics analysis. Forty pathogens,...

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Veröffentlicht in:Infection and drug resistance Jg. 17; S. 4665 - 4683
Hauptverfasser: Zhao, Min, Yang, Changyi, Zhu, Linhong, Guo, Xiaoqian, Ma, Haiyan, Luo, Yuanhao, Wang, Qi, Chen, Juanjuan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New Zealand Dove Medical Press Limited 01.01.2024
Taylor & Francis Ltd
Dove
Dove Medical Press
Schlagworte:
Alcohol
Amino acids
Bacteria
Bacterial pneumonia
biomarkers identification
Biosynthesis
Carbohydrate metabolism
Correlation analysis
Dentists
Diabetes
Folic acid
Genetic testing
Gum disease
Immune response
Metabolites
Metabolomics
Metagenomics
microbial metabolites profiling
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Muscle contraction
Oral hygiene
oral microbiota composition
Original Research
Pathogens
Periodontitis
Phenols
Pneumonia
predicted functional modules
Pregnancy
pregnancy-induced periodontitis
Pregnant women
Premature birth
Public-private sector cooperation
Pyruvic acid
Rankings
Signal transduction
Smooth muscle
Somatotropin
Teeth
TOR protein
Type 2 diabetes
Womens health
China
predicted functional modules
biomarkers identification
microbial metabolites profiling
oral microbiota composition
Pregnancy-induced periodontitis
ISSN:1178-6973, 1178-6973
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Zusammenfassung:Our study investigated the disparities and correlations between oral microbiota and metabolites in pregnant patients with and without periodontitis. Subgingival plaque samples from all subjects were collected for shotgun metagenomic sequencing and broad-target metabolomics analysis. Forty pathogens, including , , , , , group, Selenomonas sputigena etc, were significantly enriched in pregnant patients with periodontitis (PPP). Conversely, symbiotic species such as , , , , and were significantly more abundant in healthy controls (HCs). A total of 87 predicted functional modules (PFMs) exhibited significant differences between the two groups; eight PFMs showed high enrichment in PPP with involvement of PPP-enriched species within these pathways. The remaining 79 PFMs encompassing ribonucleotide biosynthesis, carbohydrate, and amino acid metabolism were highly abundant in HCs. For oral microbial metabolome, a total of 105 metabolites related to 150 KEGG pathways displayed significant differences between the two groups. Pathways such as pyruvate metabolism, folate biosynthesis, vascular smooth muscle contraction, and AMPK/mTOR signaling pathway along with their associated metabolites were found to be enriched in PPP, while carbohydrate metabolism predominated among HCs. Spearman's rank correlation analysis revealed significant positive associations between species enriched in PPP and metabolites enriched in PPP, but significant negative associations between species enriched in PPP and metabolites enriched in HCs. Our findings provide potential biomarkers for distinguishing periodontitis during pregnancy while offering valuable insights into mechanisms exploration and clinical intervention.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S475164