Diagnostics in Waldenström's macroglobulinemia: a consensus statement of the European Consortium for Waldenström's Macroglobulinemia

The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understandi...

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Published in:Leukemia Vol. 37; no. 2; pp. 388 - 395
Main Authors: Dogliotti, Irene, Jiménez, Cristina, Varettoni, Marzia, Talaulikar, Dipti, Bagratuni, Tina, Ferrante, Martina, Pérez, José, Drandi, Daniela, Puig, Noemí, Gilestro, Milena, García-Álvarez, María, Owen, Roger, Jurczak, Wojciech, Tedeschi, Alessandra, Leblond, Veronique, Kastritis, Efstathios, Kersten, Marie José, D'Sa, Shirley, Kaščák, Michal, Willenbacher, Wolfgang, Roccaro, Aldo M, Poulain, Stephanie, Morel, Pierre, Kyriakou, Charalampia, Fend, Falko, Vos, Josephine M I, Dimopoulos, Meletios A, Buske, Christian, Ferrero, Simone, García-Sanz, Ramón
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.02.2023
Subjects:
Clinical medicine
Consortia
Diagnosis
Flow cytometry
Fluorescence
Fluorescence in situ hybridization
Humans
Immunoglobulin M
In Situ Hybridization, Fluorescence
Lymphoma
Macroglobulinemia
Monoclonal gammopathy
Waldenstrom Macroglobulinemia - diagnosis
Workflow
ISSN:0887-6924, 1476-5551, 1476-5551
Online Access:Get full text
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Summary:The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström's Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.
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ISSN:0887-6924
1476-5551
1476-5551
DOI:10.1038/s41375-022-01762-3