Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials
Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have rec...
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| Vydáno v: | Nature materials Ročník 14; číslo 3; s. 352 - 360 |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
01.03.2015
Nature Publishing Group |
| Témata: | |
| ISSN: | 1476-1122, 1476-4660, 1476-4660 |
| On-line přístup: | Získat plný text |
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| Abstract | Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have recently been realized for cells in culture, the impact of
in vivo
temporal ligand presentation on cell–material responses is unknown. Here, we present a general strategy to temporally and spatially control the
in vivo
presentation of bioligands using cell-adhesive peptides with a protecting group that can be easily removed via transdermal light exposure to render the peptide fully active. We demonstrate that non-invasive, transdermal time-regulated activation of cell-adhesive RGD peptide on implanted biomaterials regulates
in vivo
cell adhesion, inflammation, fibrous encapsulation, and vascularization of the material. This work shows that triggered
in vivo
presentation of bioligands can be harnessed to direct tissue reparative responses associated with implanted biomaterials.
Transdermal light-triggered activation of cell-adhesive peptides on the surface of implanted hydrogels alters cell–material interactions, such as cell adhesion and spatial patterning, and fibrous encapsulation and vascularization of the material. |
|---|---|
| AbstractList | Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have recently been realized for cells in culture, the impact of in vivo temporal ligand presentation on cell-material responses is unknown. Here, we present a general strategy to temporally and spatially control the in vivo presentation of bioligands using cell-adhesive peptides with a protecting group that can be easily removed via transdermal light exposure to render the peptide fully active. We demonstrate that non-invasive, transdermal time-regulated activation of cell-adhesive RGD peptide on implanted biomaterials regulates in vivo cell adhesion, inflammation, fibrous encapsulation, and vascularization of the material. This work shows that triggered in vivo presentation of bioligands can be harnessed to direct tissue reparative responses associated with implanted biomaterials.Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have recently been realized for cells in culture, the impact of in vivo temporal ligand presentation on cell-material responses is unknown. Here, we present a general strategy to temporally and spatially control the in vivo presentation of bioligands using cell-adhesive peptides with a protecting group that can be easily removed via transdermal light exposure to render the peptide fully active. We demonstrate that non-invasive, transdermal time-regulated activation of cell-adhesive RGD peptide on implanted biomaterials regulates in vivo cell adhesion, inflammation, fibrous encapsulation, and vascularization of the material. This work shows that triggered in vivo presentation of bioligands can be harnessed to direct tissue reparative responses associated with implanted biomaterials. Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have been recently realized for cells in culture, the impact of in vivo temporal ligand presentation on cell-material responses is unknown. Here, we present a general strategy to temporally and spatially control the in vivo presentation of bioligands using cell adhesive peptides with a protecting group that can be easily removed via transdermal light exposure to render the peptide fully active. We demonstrate that non-invasive, transdermal time-regulated activation of cell-adhesive RGD peptide on implanted biomaterials regulates in vivo cell adhesion, inflammation, fibrous encapsulation, and vascularization of the material. This work shows that triggered in vivo presentation of bioligands can be harnessed to direct tissue reparative responses associated with implanted biomaterials. Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have recently been realized for cells in culture, the impact of in vivo temporal ligand presentation on cell-material responses is unknown. Here, we present a general strategy to temporally and spatially control the in vivo presentation of bioligands using cell-adhesive peptides with a protecting group that can be easily removed via transdermal light exposure to render the peptide fully active. We demonstrate that non-invasive, transdermal time-regulated activation of cell-adhesive RGD peptide on implanted biomaterials regulates in vivo cell adhesion, inflammation, fibrous encapsulation, and vascularization of the material. This work shows that triggered in vivo presentation of bioligands can be harnessed to direct tissue reparative responses associated with implanted biomaterials. Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have recently been realized for cells in culture, the impact of in vivo temporal ligand presentation on cell–material responses is unknown. Here, we present a general strategy to temporally and spatially control the in vivo presentation of bioligands using cell-adhesive peptides with a protecting group that can be easily removed via transdermal light exposure to render the peptide fully active. We demonstrate that non-invasive, transdermal time-regulated activation of cell-adhesive RGD peptide on implanted biomaterials regulates in vivo cell adhesion, inflammation, fibrous encapsulation, and vascularization of the material. This work shows that triggered in vivo presentation of bioligands can be harnessed to direct tissue reparative responses associated with implanted biomaterials. Transdermal light-triggered activation of cell-adhesive peptides on the surface of implanted hydrogels alters cell–material interactions, such as cell adhesion and spatial patterning, and fibrous encapsulation and vascularization of the material. Transdermal light-triggered activation of cell-adhesive peptides on the surface of implanted hydrogels alters cell-material interactions, such as cell adhesion and spatial patterning, and fibrous encapsulation and vascularization of the material. |
| Author | Shafiq, Zahid del Campo, Aránzazu Phelps, Edward A. Singh, Ankur Weis, Simone García, José R. Paez, Julieta I. Lee, Ted T. García, Andrés J. Shekaran, Asha |
| AuthorAffiliation | 4 Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA 3 Max-Planck-Institut für Polymerforschung, Mainz 55128, Germany 1 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA 2 Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA |
| AuthorAffiliation_xml | – name: 2 Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA – name: 4 Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA – name: 3 Max-Planck-Institut für Polymerforschung, Mainz 55128, Germany – name: 1 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA |
| Author_xml | – sequence: 1 givenname: Ted T. surname: Lee fullname: Lee, Ted T. organization: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology – sequence: 2 givenname: José R. surname: García fullname: García, José R. organization: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology – sequence: 3 givenname: Julieta I. surname: Paez fullname: Paez, Julieta I. organization: Max-Planck-Institut für Polymerforschung – sequence: 4 givenname: Ankur surname: Singh fullname: Singh, Ankur organization: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Sibley School of Mechanical and Aerospace Engineering, Cornell University – sequence: 5 givenname: Edward A. surname: Phelps fullname: Phelps, Edward A. organization: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology – sequence: 6 givenname: Simone surname: Weis fullname: Weis, Simone organization: Max-Planck-Institut für Polymerforschung – sequence: 7 givenname: Zahid surname: Shafiq fullname: Shafiq, Zahid organization: Max-Planck-Institut für Polymerforschung – sequence: 8 givenname: Asha surname: Shekaran fullname: Shekaran, Asha organization: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology – sequence: 9 givenname: Aránzazu surname: del Campo fullname: del Campo, Aránzazu organization: Max-Planck-Institut für Polymerforschung – sequence: 10 givenname: Andrés J. surname: García fullname: García, Andrés J. email: andres.garcia@me.gatech.edu organization: Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25502097$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2014 Copyright Nature Publishing Group Mar 2015 |
| Copyright_xml | – notice: Springer Nature Limited 2014 – notice: Copyright Nature Publishing Group Mar 2015 |
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| Snippet | Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although... Transdermal light-triggered activation of cell-adhesive peptides on the surface of implanted hydrogels alters cell-material interactions, such as cell adhesion... |
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| SubjectTerms | 639/301/54 Activation Adhesion Adhesives Animals Biocompatibility Biocompatible Materials - chemistry Biomaterials Biomedical materials Cell adhesion Cell adhesion & migration Cell Adhesion - drug effects Cell Adhesion - immunology Cell Adhesion - radiation effects Cell Adhesion Molecules - adverse effects Cell Adhesion Molecules - radiation effects Cell Line Condensed Matter Physics Drug Eruptions - immunology Fibroblasts - drug effects Fibroblasts - immunology Fibroblasts - pathology Humans Hydrogels In vivo testing In vivo tests Light Male Materials Science Mice Mice, Inbred BALB C Nanotechnology Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - immunology NIH 3T3 Cells Oligopeptides - adverse effects Oligopeptides - radiation effects Optical and Electronic Materials Peptides Studies Surgical implants |
| Title | Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials |
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