A general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides

A general anti-Baldwin radical 4-exo-dig cyclization from nitrogen-substituted alkynes is reported. Upon reaction with a heteroleptic copper complex in the presence of an amine and under visible light irradiation, a range of ynamides were shown to smoothly cyclize to the corresponding azetidines, us...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 560 - 8
Main Authors:	Jacob, Clément, Baguia, Hajar, Dubart, Amaury, Oger, Samuel, Thilmany, Pierre, Beaudelot, Jérôme, Deldaele, Christopher, Peruško, Stefano, Landrain, Yohann, Michelet, Bastien, Neale, Samuel, Romero, Eugénie, Moucheron, Cécile, Van Speybroeck, Veronique, Theunissen, Cédric, Evano, Gwilherm
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.01.2022 Nature Publishing Group Nature Portfolio
Subjects:	119/118 639/638/403 639/638/403/933 639/638/77/890 Alkynes Atmospheric chemistry Catalysis Chemical bonds Chemical Sciences Chemical synthesis Construction Coordination compounds Copper Copper compounds Efficiency Humanities and Social Sciences Irradiation Light irradiation multidisciplinary Natural products Nitrogen Photochemicals Photoredox catalysis Regioselectivity Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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