Neoantigen quality predicts immunoediting in survivors of pancreatic cancer

Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate a population. Although proven in mice 1 , 3 , whether immunoediting occurs naturally in human cancers remains unclear. Here, to address this...

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Veröffentlicht in:	Nature (London) Jg. 606; H. 7913; S. 389 - 395
Hauptverfasser:	Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 09.06.2022 Nature Publishing Group
Schlagworte:	631/57/2266 631/67/580/1884 631/67/69 Antigens Cancer Cloning Discrimination Evolution Humanities and Social Sciences Hypotheses Immune system Immunogenicity Life Sciences Lymphocytes Lymphocytes T Major histocompatibility complex multidisciplinary Mutation Neoantigens Pancreatic cancer Peptides Physics Science Science (multidisciplinary) Survival T cell receptors Thymus gland Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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