Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat

Modern lifestyle exposes nearly all humans to electromagnetic fields, particularly to extremely low frequency electromagnetic fields (ELF-EMFs). Prolonged exposure to ELF-EMFs induces persistent changes in neuronal activity. However, the modulation of synaptic efficiency by ELF-EMFs in vivo is still...

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Vydané v:Brain research Ročník 1564; s. 1 - 8
Hlavní autori: Komaki, Alireza, Khalili, Afshin, Salehi, Iraj, Shahidi, Siamak, Sarihi, Abdolrahman
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Amsterdam Elsevier B.V 20.05.2014
Elsevier
Predmet:
Animals
Biological and medical sciences
Electromagnetic Fields
Extremely low-frequency magnetic field
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - physiology
Long-Term Potentiation
Male
Neurology
Neurons - physiology
Rat
Rats
Rats, Wistar
Vertebrates: nervous system and sense organs
Rat
Long-term potentiation
Hippocampus
Extremely low-frequency magnetic field
Rodentia
Central nervous system
Low frequency
Encephalon
Vertebrata
Mammalia
Animal
Synaptic plasticity
Electromagnetic field
Magnetic field
ISSN:0006-8993, 1872-6240, 1872-6240
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Shrnutí:Modern lifestyle exposes nearly all humans to electromagnetic fields, particularly to extremely low frequency electromagnetic fields (ELF-EMFs). Prolonged exposure to ELF-EMFs induces persistent changes in neuronal activity. However, the modulation of synaptic efficiency by ELF-EMFs in vivo is still unclear. In the present study, we investigated whether ELF-EMFs can change induction of long-term potentiation (LTP) and paired-pulse ratio (PPR) in the rat hippocampal area. Twenty-nine adult male Wistar rats were divided into 3 groups (ELF-EMF exposed, sham and control groups). The ELF-EMF group was exposed to a magnetic field for 90 consecutive days (2h/day). ELF-EMFs were produced by a circular coil (50Hz, 100 micro Tesla). The sham-exposed controls were placed in an identical chamber with no electromagnetic field. After this period, rats were deeply anesthetized with urethane (2.0mg/kg) and then a bipolar stimulating and recording electrode was implanted into the perforant pathway (PP) and dentate gyrus (DG), respectively. LTP in hippocampal area was induced by high-frequency stimulation (HFS). Prolonged exposure to ELF-EMFs increased LTP induction. There was a significant difference in the slope of EPSP and amplitude of PS between the ELF-EMF group and other groups. In conclusion, our data suggest that exposure to ELF-EMFs produces a marked change in the synaptic plasticity generated in synapses of the PP-DG. No significant difference in PPR of ELF-EMF group before and after HFS suggests a postsynaptic expression site of LTP. •Exposure to electromagnetic fields is increasing with use of electrical appliances.•Extremely low frequency electromagnetic fields (ELF-EMFs) produces effects on cognition.•Exposure to ELF-EMFs induces persistent changes in long-term potentiation (LTP).•ELF-EMFs have no significant effects on paired-pulse ratio (PPR).•No significant difference in the PPR of ELF-EMFs, suggests a postsynaptic site of LTP.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0006-8993
1872-6240
1872-6240
DOI:10.1016/j.brainres.2014.03.041