Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone

Methotrexate (MTX) is a drug used in treatment of various malignancies. Unfortunately, it leads to life-threatening complications including hepatorenal toxicity. Previous studies revealed the protective effects of metformin (MET) on hepatorenal toxicity in other models in addition to its anticancer...

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Bibliographic Details
Published in:	Journal of inflammation research Vol. 11; pp. 421 - 429
Main Authors:	Rizk, Fatma H., El Saadany, Amira A., Dawood, Lamees, Elkaliny, Heba H., Sarhan, Naglaa I., Badawi, Rehab, Abd-Elsalam, Sherief
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01.01.2018 Taylor & Francis Ltd Dove Medical Press
Subjects:	Antidiabetics Antineoplastic agents Antioxidants Antioxidants (Nutrients) Apoptosis Arthritis ATPases B cells Biochemistry Cancer therapies Cancer treatment Chemotherapy Complications and side effects COX-2 inhibitors Cytotoxicity Drug dosages EDTA Enzymes Experiments Hepatorenal toxicity Immunomodulators Kidneys Kinases Laboratory animals Liver Medical research Medicine Messenger RNA Metformin Methotrexate Mitochondria Original Research Oxidative stress Proteins RNA Toxicity Type 2 diabetes United States > US Egypt hepatorenal toxicity metformin methotrexate
ISSN:	1178-7031, 1178-7031
Online Access:	Get full text
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