Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002-2006

Background: A reduced heart rate variability (HRV) is associated with worse prognosis, increased incidence of cardiovascular disease (CVD) and mortality. There are conflicting results and a lack of population-based data regarding the association of HRV with CVD risk factors and its potential role as...

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Bibliographic Details
Published in:European journal of epidemiology Vol. 24; no. 3; pp. 123 - 142
Main Authors: Greiser, Karin Halina, Kluttig, Alexander, Schumann, Barbara, Swenne, Cees A, Kors, Jan A, Kuss, Oliver, Haerting, Johannes, Schmidt, Hendrik, Thiery, Joachim, Werdan, Karl
Format: Journal Article
Language:English
Published: Dordrecht Dordrecht : Springer Netherlands 01.03.2009
Springer
Springer Netherlands
Springer Nature B.V
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Cardiology
Cardiovascular Disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cholesterols
Cross-Sectional Studies
Diabetes
Electrocardiography
Epidemiology
Exercise
Female
General aspects
Germany - epidemiology
Health risks
Heart rate
Heart Rate - physiology
Humans
Hypertension
Infectious Diseases
Interviews as Topic
Male
Medical sciences
Medicine
Medicine & Public Health
Men
Middle Aged
Miscellaneous
Older adults
Older people
Oncology
Physical Examination
Public Health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Risk taking
Germany
Population-based study
Cardiovascular disease
Cardiovascular risk factors
Heart rate variability
Human
Short term
Cardiac frequency
Variability
Epidemiology
Statistical study
Heart rate
Risk factor
Cardiovascular risk
Population
Elderly
Public health
ISSN:0393-2990, 1573-7284, 1573-7284
Online Access:Get full text
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Summary:Background: A reduced heart rate variability (HRV) is associated with worse prognosis, increased incidence of cardiovascular disease (CVD) and mortality. There are conflicting results and a lack of population-based data regarding the association of HRV with CVD risk factors and its potential role as independent cause or mediator of CVD risk. Methods: Cross-sectional data of a population-based cohort including 1,779 women and men aged 45-83 years were used to analyse associations of time and frequency domain measures of HRV (derived from 5-min ECG segments) with age, behavioural and biomedical risk factors and disease in the whole sample and in a “healthy” subgroup. Results: Age was inversely associated with all measures of HRV (mean standard deviation of normal intervals across 10-year age-groups 32.1, 26.9, 27.1 and 24.8 ms in women, 29.3, 25.9, 23.8 and 25.7 ms in men). There was no association of physical activity, current smoking or alcohol with HRV. In age-adjusted models, triglycerides, glucose, waist-to-hip ratio and diabetes were inversely associated with HRV in men and women, and low/high density cholesterol and hypertension in men only (up to 43% difference across risk factor quartiles). Multivariable adjustment and restriction to the “healthy” subgroup attenuated the associations. Conclusions: We found only weak and inconsistent associations of HRV with cardiovascular risk factors. However, these results as well as those from previous studies are still compatible with the hypothesis that short-term HRV may be a marker of ill health or a mediator of the effect of selected biomedical risk factors on CVD.
Bibliography:http://dx.doi.org/10.1007/s10654-009-9317-z
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ISSN:0393-2990
1573-7284
1573-7284
DOI:10.1007/s10654-009-9317-z