Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review

Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical propertie...

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Veröffentlicht in:Marine drugs Jg. 21; H. 5; S. 299
Hauptverfasser: Jiang, Feng, Xu, Xin-Wei, Chen, Fu-Quan, Weng, Hui-Fen, Chen, Jun, Ru, Yi, Xiao, Qiong, Xiao, An-Feng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 14.05.2023
MDPI
Schlagworte:
Agarose
Algae
bioactive properties
Biocompatibility
biocompatible materials
Biocompatible Materials - chemistry
Biological activity
Biological products
Biological properties
Biomaterials
biomedical application
Biomedical materials
Cellulose
Chemical engineering
Chemical engineering research
Chemical properties
Colloids
Drug delivery
Drug Delivery Systems
Drugs
Ethanol
Extraction (Chemistry)
Health aspects
hydrogel
Hydrogels
Hydrogels - chemistry
Hydrogen bonds
industry
Ions
Marine algae
Materials
Mechanical properties
Medical dressings
Medical supplies
Methods
modification
Polyethylene glycol
Polysaccharides
Production processes
Purification
Red algae
Review
Sepharose - chemistry
Solvents
Three dimensional printing
Tissue Engineering
Vehicles
Water purification
China
biomedical application
hydrogel
modification
agarose
ISSN:1660-3397, 1660-3397
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Zusammenfassung:Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical properties, and high biological activity. Natural agarose hydrogel has a single structural composition that prevents it from adapting to complex biological environments. Therefore, agarose can be developed into different forms through physical, biological, and chemical modifications, enabling it to perform optimally in different environments. Agarose biomaterials are being increasingly used for isolation, purification, drug delivery, and tissue engineering, but most are still far from clinical approval. This review classifies and discusses the preparation, modification, and biomedical applications of agarose, focusing on its applications in isolation and purification, wound dressings, drug delivery, tissue engineering, and 3D printing. In addition, it attempts to address the opportunities and challenges associated with the future development of agarose-based biomaterials in the biomedical field. It should help to rationalize the selection of the most suitable functionalized agarose hydrogels for specific applications in the biomedical industry.
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These authors contributed equally to this paper.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21050299