First report of epidemic dengue fever and malaria co-infections among internally displaced persons in humanitarian camps of North Darfur, Sudan

This study aimed to investigate an outbreak of a non-malaria, undifferentiated febrile illness, among internally displaced persons (IDPs) living in humanitarian camps in North Darfur, Sudan, in 2019. An investigation team was deployed to North Darfur to identify suspected cases and collect blood sam...

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Vydáno v:International journal of infectious diseases Ročník 108; s. 513 - 516
Hlavní autoři: Ahmed, Ayman, Eldigail, Mawahib, Elduma, Adel, Breima, Tagwa, Dietrich, Isabelle, Ali, Yousif, Weaver, Scott C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Canada Elsevier Ltd 01.07.2021
Elsevier
Témata:
Arboviruses
Coinfection - epidemiology
Dengue - epidemiology
Dengue Virus - genetics
Dengue with warning signs (DWWS)
Disease Outbreaks
Epidemic
Epidemics
Humans
Malaria - epidemiology
outbreak
Phylogeny
Refugees
Severe dengue fever (SD)
Sudan
Sudan - epidemiology
Sudan
Epidemic
Dengue with warning signs (DWWS)
Arboviruses
outbreak
Severe dengue fever (SD)
Sudan
ISSN:1201-9712, 1878-3511, 1878-3511
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Shrnutí:This study aimed to investigate an outbreak of a non-malaria, undifferentiated febrile illness, among internally displaced persons (IDPs) living in humanitarian camps in North Darfur, Sudan, in 2019. An investigation team was deployed to North Darfur to identify suspected cases and collect blood samples, and clinical and demographical data. Blood samples were examined microscopically for Plasmodium spp and tested for dengue (DENV) and yellow fever viruses by reverse transcriptase-quantitative polymerase chain reaction. Between September 7 and December 18, 2019, we clinically identified 18 (24%), 41 (54%), and 17 (22%) cases of dengue fever, dengue with warning signs, and severe dengue, respectively. Blood samples were collected from 22% of patients, and 47% of these tested positive for DENV-1 RNA. We confirmed 32 malaria cases with 5 co-infections with DENV. This outbreak of dengue was the first among IDPs in the humanitarian camps. Our findings indicate that dengue has become endemic or that there has been a new introduction. Further epidemiological, entomological, and phylogenetic studies are needed to understand disease transmission in the area. An early warning and response system and an effective health policy are crucial for preventing and controlling arboviruses in Sudan.
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content type line 23
Conceptualization, A.A. and Y.A.; methodology, A.A., Y.A., M.E., and AE, formal analysis, A.A. and Y.A.; investigation, Y.A., and T.B.; writing—original draft preparation, A.A.; writing—review and editing, A.A. M.E., A.E., T.B., I.D., Y.A., and S.C.W.
Author contributions
ISSN:1201-9712
1878-3511
1878-3511
DOI:10.1016/j.ijid.2021.05.052