Dysfunction of Protein Quality Control in Parkinsonism–Dementia Complex of Guam

Guam parkinsonism-dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologically, G-PDC is characterized by abundant neurofibrillar...

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Bibliographic Details

Published in:	Frontiers in neurology Vol. 9; p. 173
Main Authors:	Verheijen, Bert M., Oyanagi, Kiyomitsu, van Leeuwen, Fred W.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 20.03.2018
Subjects:	Guam parkinsonism–dementia complex mutant ubiquitin neurofibrillary tangles Neuroscience protein aggregation protein quality control tau mutant ubiquitin Guam parkinsonism–dementia complex protein aggregation neurofibrillary tangles protein quality control tau 43-kDa TAR DNA-binding protein neuropathology
ISSN:	1664-2295, 1664-2295
Online Access:	Get full text
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