oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes

SCOPE: Curcumin revealed various health‐beneficial properties in numerous studies. However its bioavailability is low due to its limited intestinal uptake and rapid metabolism. The aim of our project was to develop novel curcumin formulations with improved oral bioavailability and to study their saf...

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Veröffentlicht in:Molecular nutrition & food research Jg. 58; H. 3; S. 516 - 527
Hauptverfasser: Schiborr, Christina, Kocher, Alexa, Behnam, Dariush, Jandasek, Josef, Toelstede, Simone, Frank, Jan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim Blackwell Publishing Ltd 01.03.2014
Wiley
Schlagworte:
absorption
Administration, Oral
Bioavailability
Biological and medical sciences
Biological Availability
blood
Cross-Over Studies
Curcuma longa
Curcumin
Curcumin - adverse effects
Curcumin - analogs & derivatives
Curcumin - analysis
Curcumin - metabolism
Curcumin - pharmacokinetics
Diarylheptanoids
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
gender differences
Healthy humans
Humans
Male
men
Micelles
Powders
Safety
Sex differences
Sex Factors
urine
Vertebrates: anatomy and physiology, studies on body, several organs or systems
women
Young Adult
Human
Monocotyledones
Curcuma longal
Nutrition
Tyrosine kinase inhibitor
Toxicity
Sex
Oral administration
Micelle
Sex differences
Healthy humans
Bioavailability
Powder
Liquid
Angiospermae
Spermatophyta
Curcumin
Curcuma
Safety
Pharmacokinetics
Zingiberaceae
Curcuma longa
ISSN:1613-4125, 1613-4133, 1613-4133
Online-Zugang:Volltext
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Zusammenfassung:SCOPE: Curcumin revealed various health‐beneficial properties in numerous studies. However its bioavailability is low due to its limited intestinal uptake and rapid metabolism. The aim of our project was to develop novel curcumin formulations with improved oral bioavailability and to study their safety as well as potential sex‐differences. METHODS AND RESULTS: In this crossover study, healthy subjects (13 women, 10 men) took, in random order, a single oral dose of 500 mg curcuminoids as native powder, micronized powder, or liquid micelles. Blood and urine samples were collected for 24 h and total curcuminoids and safety parameters were quantified. Based on the area under the plasma concentration–time curve (AUC), the micronized curcumin was 14‐, 5‐, and 9‐fold and micellar curcumin 277‐, 114‐, and 185‐fold better bioavailable than native curcumin in women, men, and all subjects, respectively. Thus, women absorbed curcumin more efficiently than men. All safety parameters remained within the reference ranges following the consumption of all formulations. CONCLUSION: Both, the micronized powder and in particular the liquid micellar formulation of curcumin significantly improved its oral bioavailability without altering safety parameters and may thus be ideally suited to deliver curcumin in human intervention trials. The observed sex differences in curcumin absorption warrant further investigation.
Bibliographie:http://dx.doi.org/10.1002/mnfr.201300724
ark:/67375/WNG-Z3F6XZ74-P
istex:23392DC554ADABE90D6AC323FD532528647A4D10
German Federal Ministry of Education and Research (BMBF) - No. 01EA1334A
ArticleID:MNFR2145
The trial was registered at clinicaltrials.gov with the study ID NCT01925287.
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ISSN:1613-4125
1613-4133
1613-4133
DOI:10.1002/mnfr.201300724