Transcriptional profiling reveals functional dichotomy between human slan+ non‐classical monocytes and myeloid dendritic cells

Slan+ non‐classical monocytes are equipped with a distinctive immunological gene set compared to DCs, and harbor monocyte‐like functional features. Human 6‐sulfo LacNac‐positive (slan+) cells have been subject to a paradigm debate. They have previously been classified as a distinct dendritic cell (D...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 102; no. 4; pp. 1055 - 1068
Main Authors:	Leeuwen‐Kerkhoff, Nathalie, Lundberg, Kristina, Westers, Theresia M., Kordasti, Shahram, Bontkes, Hetty J., Gruijl, Tanja D., Lindstedt, Malin, Loosdrecht, Arjan A.
Format:	Journal Article
Language:	English
Published:	Bethesda, MD, USA Society for Leukocyte Biology 01.10.2017 Oxford University Press
Subjects:	Antigen presentation Antigens, CD1 - immunology Antigens, Surface - immunology Basic Medicine CD141+ DC CD1c antigen CD1c+ DC CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell and Molecular Biology Cell surface Cell- och molekylärbiologi Complement receptors Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Gene expression Gene Expression Profiling Genomes Glycoproteins - immunology Humans Immunity Immunology Inflammation Interleukin 6 Interleukin-1beta - immunology Interleukin-6 - immunology Lymphocytes Lymphocytes T Major histocompatibility complex Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper microarray Monocytes Monocytes - cytology Monocytes - immunology M‐DC8+ cells Peripheral blood Receptors Specialization Transcription Transcription, Genetic - immunology Tumor Suppressor Proteins microarray M-DC8+ cells CD1c+ DC CD141+ DC
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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