Bioactive Peptide Brush Polymers via Photoinduced Reversible‐Deactivation Radical Polymerization

Harnessing metal‐free photoinduced reversible‐deactivation radical polymerization (photo‐RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme‐responsive and pro‐apoptotic peptide brush polymers. Thermolysin‐responsive peptide‐based polymeric amphiphiles assembled into spheri...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 58; no. 48; pp. 17359 - 17364
Main Authors:	Sun, Hao, Choi, Wonmin, Zang, Nanzhi, Battistella, Claudia, Thompson, Matthew P., Cao, Wei, Zhou, Xuhao, Forman, Christopher, Gianneschi, Nathan C.
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 25.11.2019 Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Acrylates - chemistry Amino Acids - chemistry Apoptosis Biocompatibility Biological activity biomaterials Brushes Cell Membrane Permeability - drug effects Cell Survival - drug effects Chemistry Chemistry, Multidisciplinary Cytotoxicity Deactivation Ductile-brittle transition Enzymes Fracture mechanics Free Radicals - chemistry HeLa Cells Humans Micelles Molecular Conformation Morphology nanomaterials Nanoparticles Nanoparticles - chemistry peptide brush polymer Peptides Peptides - chemistry Photochemical Processes photochemistry Physical Sciences Polymerization Polymers Polymers - chemistry Polymethyl Methacrylate - chemistry Science & Technology Solvents - chemistry Structure-Activity Relationship Thermolysin Thermolysin - chemistry Toxicity OXYGEN polymerization MECHANISM ROBUST photochemistry nanomaterials peptide brush polymer biomaterials
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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