Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll‐like receptor 9 in mice

Sterile inflammatory insults are known to activate innate immunity and propagate organ damage through the recognition of extracellular damage‐associated molecular pattern (DAMP) molecules. Although DAMPs such as endogenous DNA and nuclear high‐mobility group box 1 have been shown to be critical in s...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 54; no. 3; pp. 999 - 1008
Main Authors:	Huang, Hai, Evankovich, John, Yan, Wei, Nace, Gary, Zhang, Lemeng, Ross, Mark, Liao, Xinghua, Billiar, Timothy, Xu, Jun, Esmon, Charles T., Tsung, Allan
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 02.09.2011 Wiley Wolters Kluwer Health, Inc
Subjects:	Animals Biological and medical sciences Cells, Cultured Gastroenterology. Liver. Pancreas. Abdomen Hepatology Histones - physiology HMGB1 Protein - physiology Immunity, Innate Inflammation Inflammation - etiology Liver - blood supply Liver Injury/Regeneration Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 - physiology Reperfusion Injury - prevention & control Rodents Signal Transduction Toll-Like Receptor 9 - physiology Vertebrata Mammalia Mouse Animal Liver Rodentia Gastroenterology Toll like receptor
ISSN:	0270-9139, 1527-3350, 1527-3350
Online Access:	Get full text
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