Lung-function trajectories: relevance and implementation in clinical practice

Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the lif...

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Published in:The Lancet (British edition) Vol. 403; no. 10435; pp. 1494 - 1503
Main Authors: Melén, Erik, Faner, Rosa, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, Agusti, Alvar, Abellan, Alicia, Adcock, Ian, Afzal, Shoaib, Alter, Peter, Backman, Helena, Bertels, Xander, Bloom, Chloe, Bønnelykke, Klaus, Breyer, Marie-Kathrin, Casas, Sandra, Chung, Fan (Kian), Colak, Yunus, Cosio, Borja G., Duijts, Liesbeth, Fabbri, Leonardo, Fontanella, Sara, Fuertes, Elaine, Gonzalez, Juan Ramón, Granell, Raquel, Hartl, Sylvia, Hernandez-Pacheco, Natalia, Holloway, John, Jarvis, Deborah, Koefoed, Hans Jacob, Kole, Tessa, Kumar, Ashish, Langhammer, Arnulf, Lindberg, Anne, Llopis, Maria, Maitland van der Zee, Anke-Hilse, Meteran, Howraman, Minelli, Cosetta, Nwaru, Bright, Olvera, Nuria, Peralta, Gabriela, Ritchie, Andrew, Rönmark, Eva, Ross Chapman, James, Sangüesa Boix, Júlia, Schikowski, Tamara, Schlünssen, Vivi, Shaheen, Seif, Sigsgaard, Torben, Standl, Marie, Talaei, Mohammad, Ullah, Anhar, Ullman, Anders, Valencia-Hernandez, Carlos, van den Berge, Maarten, van Dijk, Yoni, Vestbo, Jørgen, Vijverberg, Susanne, Vikjord, Sigrid Anna, Volgelmeier, Claus, Vonk, Judith, Zounemat Kermani, Nazanin
Format: Journal Article
Language:English
Published: England Elsevier Ltd 13.04.2024
Elsevier Limited
Subjects:
Adolescent
Adult
Age
Aging
Airway management
Asthma
Body height
Charts
Child
Child development
Children
Chronic obstructive pulmonary disease
Clinical medicine
Comorbidity
Environmental factors
Exercise
Health Status
Humans
Infections
Longitudinal studies
Lung
Lungmedicin och allergi
Lungs
Mental Health
Respiratory diseases
Respiratory function
Respiratory Medicine and Allergy
Respiratory Tract Diseases
Risk factors
Smoking
Spirometry
Tobacco
Young adults
ISSN:0140-6736, 1474-547X, 1474-547X
Online Access:Get full text
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Summary:Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population. Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death. This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health. Specifically, we propose that, similar to paediatric height and weight charts used globally to monitor children's growth, lung-function charts could be used for both children and adults to monitor lung health status across the life course. To achieve this proposal, we introduce our free online Lung Function Tracker tool. Finally, we discuss challenges and opportunities for effective implementation of the trajectory concept at population level and outline an agenda for crucial research needed to support such implementation.
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ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(24)00016-3