Evolutionary couplings detect side-chain interactions

Patterns of amino acid covariation in large protein sequence alignments can inform the prediction of de novo protein structures, binding interfaces, and mutational effects. While algorithms that detect these so-called evolutionary couplings between residues have proven useful for practical applicati...

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Vydané v:	PeerJ (San Francisco, CA) Ročník 7; s. e7280
Hlavní autori:	Hockenberry, Adam J., Wilke, Claus O.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States PeerJ. Ltd 08.07.2019 PeerJ, Inc PeerJ Inc
Predmet:	Accuracy Algorithms Amino acid sequence Amino acids Bioinformatics Biology Biophysics Computational Biology Contact prediction Datasets Deep learning Epistasis Evolution Evolutionary couplings Evolutionary Studies Interfaces Mutation Neural networks Protein binding Protein evolution Proteins Structural constraints United States > US Protein evolution Epistasis Evolutionary couplings Structural constraints Contact prediction
ISSN:	2167-8359, 2167-8359
On-line prístup:	Získať plný text
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