CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel

[Display omitted] •Combinational chemotherapy was used to eradicate cancer cells & cancer stem cells.•Both the anticancer drugs were delivered through polymeric nanoparticles.•Paclitaxel, a conventional chemotherapeutic agent was used to kill cancer cells.•Salinomycin was selected as cancer stem...

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Bibliographic Details
Published in:	Colloids and surfaces, B, Biointerfaces Vol. 143; pp. 532 - 546
Main Authors:	Muntimadugu, Eameema, Kumar, Rajendra, Saladi, Shantikumar, Rafeeqi, Towseef Amin, Khan, Wahid
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2016
Subjects:	antibodies Antibodies - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast breast neoplasms Cancer Cancer stem cells CD44 receptors Coating coatings colloids Combinational chemotherapy cytotoxicity Drug Carriers Drug Compounding Drug Liberation drug therapy Drugs emulsions Female flow cytometry Fluorescein-5-isothiocyanate Fluorescent Dyes Gene Expression Humans Hyaluronan Receptors - chemistry Hyaluronan Receptors - genetics Hyaluronan Receptors - immunology Hyaluronic acid Hyaluronic Acid - chemistry Hydroxyapatite inhibitory concentration 50 Lactic Acid - chemistry light scattering MCF-7 Cells Molecular Targeted Therapy - methods Nanoparticles neoplasm cells Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Paclitaxel Paclitaxel - chemistry Paclitaxel - pharmacology Particle Size Polyglycolic Acid - chemistry Polymeric nanoparticles Pyrans - chemistry Pyrans - pharmacology receptors Salinomycin solvents staining Stem cells Therapy transmission electron microscopy Combinational chemotherapy Polymeric nanoparticles Salinomycin Paclitaxel Cancer stem cells CD44 receptors Hyaluronic acid
ISSN:	0927-7765, 1873-4367, 1873-4367
Online Access:	Get full text
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