B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion

The mechanisms by which B lymphocytes inhibit anti-tumor immunity remain poorly understood. Murine EMT-6 mammary tumors grow readily in immune competent mice (BALB/c), but poorly in B-cell-deficient μ −/− BALB/c mice (BCDM). T regulatory cell (Treg) expansion and function were impaired in BCDM compa...

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Bibliographic Details
Published in:	Cancer Immunology, Immunotherapy Vol. 62; no. 1; pp. 87 - 99
Main Authors:	Zhang, Yu, Eliav, Yair, Shin, Seung-uon, Schreiber, Taylor H., Podack, Eckhard R., Tadmor, Tamar, Rosenblatt, Joseph D.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.01.2013 Springer Nature B.V
Subjects:	Adoptive Transfer Animals Antibodies Antigens B-Lymphocytes - immunology B-Lymphocytes - metabolism Cancer Cancer Research CD8 antigen Cell growth Cell Proliferation Cytokines Cytotoxicity Flow Cytometry Immunology Immunoregulation Immunosuppression Immunotherapy Interleukin 10 Interleukin-10 - immunology Interleukin-10 - metabolism Laboratories Lymphocyte Activation - immunology Lymphocytes Lymphocytes B Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Mammary gland Mammary Neoplasms, Experimental - immunology Medicine Medicine & Public Health Metastases Mice Mice, Inbred BALB C Mice, Knockout Microenvironments Oncology Original Original Article Receptor Cross-Talk - immunology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Tumor Microenvironment - immunology Tumors United States > US B lymphocyte T regulatory cells (Treg) B-cell-deficient mice (BCDM) IL-10 Immune competent mice (BALB/c)
ISSN:	0340-7004, 1432-0851, 1432-0851
Online Access:	Get full text
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