Resistance training preserves high-intensity interval training induced improvements in skeletal muscle capillarization of healthy old men: a randomized controlled trial

Skeletal muscle capillarization is a determining factor in gas and metabolite exchange, while its impairments may contribute to the development of sarcopenia. Studies on the potential of resistance training (RT) to induce angiogenesis in older muscles have been inconclusive, and effects of sequentia...

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Vydané v:Scientific reports Ročník 10; číslo 1; s. 6578 - 10
Hlavní autori: Leuchtmann, Aurel B., Mueller, Sandro Manuel, Aguayo, David, Petersen, Jens A., Ligon-Auer, Maria, Flück, Martin, Jung, Hans H., Toigo, Marco
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 20.04.2020
Nature Publishing Group
Nature Portfolio
Predmet:
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692/499
Adaptation
Adaptation, Physiological
Aged
Aging - genetics
Aging - physiology
Angiogenesis
Body Composition - physiology
Capillaries - growth & development
Capillaries - physiology
Enzymatic activity
Exercise
Female
Healthy Volunteers
Histochemistry
Humanities and Social Sciences
Humans
Interval training
Male
Metabolites
Morphology
multidisciplinary
Muscle Fibers, Skeletal - metabolism
Muscle, Skeletal - physiology
Muscles
Musculoskeletal system
Physical training
Resistance Training
Risk Factors
Sarcopenia
Sarcopenia - physiopathology
Science
Science (multidisciplinary)
Skeletal muscle
Strength training
Succinate dehydrogenase
Vascularization
ISSN:2045-2322, 2045-2322
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Shrnutí:Skeletal muscle capillarization is a determining factor in gas and metabolite exchange, while its impairments may contribute to the development of sarcopenia. Studies on the potential of resistance training (RT) to induce angiogenesis in older muscles have been inconclusive, and effects of sequential endurance training (ET) and RT on capillarization are unknown. Healthy older men (66.5 ± 3.8 years) were engaged in either 12 weeks of habitual course observation (HC) followed by 12 weeks of RT ( n  = 8), or 12 weeks of high-intensity interval training (HIIT) followed by 12 weeks of RT ( n  = 9). At baseline, following 12 and 24 weeks, m. vastus lateralis biopsies were obtained. (Immuno-)histochemistry was used to assess indices of muscle fiber capillarization, muscle fiber morphology and succinate dehydrogenase (SDH) activity. Single periods of RT and HIIT resulted in similar improvements in capillarization and SDH activity. During RT following HIIT, improved capillarization and SDH activity, as well as muscle fiber morphology remained unchanged. The applied RT and HIIT protocols were thus similarly effective in enhancing capillarization and oxidative enzyme activity and RT effectively preserved HIIT-induced adaptations of these parameters. Hence, both, RT and HIIT, are valid training modalities for older men to improve skeletal muscle vascularization.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-63490-x