Hepatitis C Virus-Lipid Interplay: Pathogenesis and Clinical Impact

Hepatitis C virus (HCV) infection represents the major cause of chronic liver disease, leading to a wide range of hepatic diseases, including cirrhosis and hepatocellular carcinoma. It is the leading indication for liver transplantation worldwide. In addition, there is a growing body of evidence con...

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Vydáno v:Biomedicines Ročník 11; číslo 2; s. 271
Hlavní autoři: Elgretli, Wesal, Chen, Tianyan, Kronfli, Nadine, Sebastiani, Giada
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 19.01.2023
MDPI
Témata:
Amino acids
Apolipoproteins
Arteriosclerosis
atherosclerosis
Cardiovascular diseases
Cholesterol
Chronic infection
Cirrhosis
Dyslipidemia
Endoplasmic reticulum
Fatty liver
Genomes
Glycoproteins
Health aspects
Hepatitis C
Hepatitis C virus
Hepatocellular carcinoma
Hypocholesterolemia
Infections
Insulin
Insulin resistance
Kinases
Life cycles
Lipid metabolism
Lipids
Lipoproteins
Liver cancer
Liver diseases
Liver transplantation
Metabolic disorders
MicroRNAs
Pathogenesis
Proteins
Review
Steatosis
Viruses
United States
atherosclerosis
cholesterol
steatosis
hepatitis C
lipid metabolism
ISSN:2227-9059, 2227-9059
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Shrnutí:Hepatitis C virus (HCV) infection represents the major cause of chronic liver disease, leading to a wide range of hepatic diseases, including cirrhosis and hepatocellular carcinoma. It is the leading indication for liver transplantation worldwide. In addition, there is a growing body of evidence concerning the role of HCV in extrahepatic manifestations, including immune-related disorders and metabolic abnormalities, such as insulin resistance and steatosis. HCV depends on its host cells to propagate successfully, and every aspect of the HCV life cycle is closely related to human lipid metabolism. The virus circulates as a lipid-rich particle, entering the hepatocyte via lipoprotein cell receptors. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation (steatosis) and circulating hypocholesterolemia. Patients with chronic HCV are at increased risk for hepatic steatosis, dyslipidemia, and cardiovascular disease, including accelerated atherosclerosis. This review aims to describe different aspects of the HCV viral life cycle as it impacts host lipoproteins and lipid metabolism. It then discusses the mechanisms of HCV-related hepatic steatosis, hypocholesterolemia, and accelerated atherosclerosis.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11020271