Effects of ketoconazole and valproic acid on the pharmacokinetics of the next generation NNRTI, lersivirine (UK‐453,061), in healthy adult subjects

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Lersivirine (UK‐453,061) is predominantly cleared by glucuronidation (UGT2B7) and oxidation via cytochrome P450 (CYP) 3A4. • Lersivirine metabolism, and thus pharmacokinetics, may be affected by concomitant administration of drugs affecting CYP3A4 and UGT2B...

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Vydané v:	British journal of clinical pharmacology Ročník 73; číslo 5; s. 768 - 775
Hlavní autori:	Langdon, Grant, Davis, John, Layton, Gary, Chong, Chew‐Lan, Weissgerber, Georges, Vourvahis, Manoli
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Blackwell Publishing Ltd 01.05.2012 Blackwell Blackwell Science Inc
Predmet:	Adult Antifungal Agents - pharmacology Area Under Curve Asian People Biological and medical sciences Cross-Over Studies Cytochrome P-450 CYP3A - metabolism Drug Interactions Enzyme Inhibitors - pharmacology Glucuronosyltransferase - metabolism Humans ketoconazole Ketoconazole - pharmacology lersivirine Male Medical sciences Middle Aged Nitriles - administration & dosage Nitriles - pharmacokinetics pharmacokinetics Pharmacology. Drug treatments Pyrazoles - administration & dosage Pyrazoles - pharmacokinetics Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - pharmacokinetics UK‐453,061 valproic acid Valproic Acid - pharmacology Young Adult United Kingdom Europe Human Imidazole derivatives 4-Aminobutyrate transaminase Healthy subject Ketoconazole Enzyme Transferases Non nucleoside compound UK-453,061 Enzyme inhibitor Anticonvulsant Valproic acid Histone deacetylase inhibitor Antifungal agent Mood stabilizer Transaminases Reverse transcriptase inhibitor Lersivirine Antiviral Pharmacokinetics
ISSN:	0306-5251, 1365-2125, 1365-2125
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