RNA covariation at helix-level resolution for the identification of evolutionarily conserved RNA structure

Many biologically important RNAs fold into specific 3D structures conserved through evolution. Knowing when an RNA sequence includes a conserved RNA structure that could lead to new biology is not trivial and depends on clues left behind by conservation in the form of covariation and variation. For...

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Veröffentlicht in:	PLoS computational biology Jg. 19; H. 7; S. e1011262
1. Verfasser:	Rivas, Elena
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.07.2023
Schlagworte:	Alignment Base pairs Benchmarks Biology and life sciences Computer and Information Sciences Conserved sequence Datasets Evolution Gene sequencing Helices Hypotheses Methods Non-coding RNA Nucleotide sequence Phylogeny Physical Sciences Physiological aspects Power Protein structure Research and Analysis Methods Ribonucleic acid RNA Secondary structure Sensitivity Statistical analysis Statistical tests Structure United States
ISSN:	1553-7358, 1553-734X, 1553-7358
Online-Zugang:	Volltext
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