Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma subtype arising from naïve B cells. Although novel therapeutics have improved patient prognosis, drug resistance remains a key problem. Here, we show that the SRC-family tyrosine kinase hematopoietic cell kinase (HCK), which is primari...

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Veröffentlicht in:	Leukemia Jg. 35; H. 3; S. 881 - 886
Hauptverfasser:	Lantermans, Hildo C., Minderman, Marthe, Kuil, Annemieke, Kersten, Marie-José, Pals, Steven T., Spaargaren, Marcel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.03.2021 Nature Publishing Group
Schlagworte:	13/1 13/109 13/2 13/31 13/89 38 38/39 38/61 42/41 631/67/1059/602 631/67/1990/291/1621/1915 631/67/395 82/29 82/80 96 Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Research Care and treatment Cell cycle Cell proliferation Cell receptors Critical Care Medicine Development and progression Drug resistance Extracellular matrix Gene expression Genetic aspects Hck protein Health aspects Hematology Humans Intensive Internal Medicine Kinases Letter Lymphocytes B Lymphoma Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Mantle cell lymphoma Medical prognosis Medicine Medicine & Public Health Microenvironments MyD88 protein Non-Hodgkin's lymphoma Oncology Phosphotransferases Prognosis Protein-tyrosine kinase Proto-Oncogene Proteins c-hck - genetics Proto-Oncogene Proteins c-hck - metabolism Signal Transduction Src protein Stromal cells Survival Therapeutic targets Toll-like receptors Tumor Microenvironment Tyrosine Netherlands
ISSN:	0887-6924, 1476-5551, 1476-5551
Online-Zugang:	Volltext
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