Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

[Display omitted] Chronic hepatitis C is a global health problem with an estimated 170 million hepatitis C virus (HCV) infected individuals at risk of progressive liver disease and hepatocellular carcinoma (HCC). Autotaxin (ATX, gene name: ENPP2) is a phospholipase with diverse roles in the physiolo...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 66; no. 5; pp. 919 - 929
Main Authors:	Farquhar, Michelle J., Humphreys, Isla S., Rudge, Simon A., Wilson, Garrick K., Bhattacharya, Bishnupriya, Ciaccia, Maria, Hu, Ke, Zhang, Qifeng, Mailly, Laurent, Reynolds, Gary M., Ashcroft, Margaret, Balfe, Peter, Baumert, Thomas F., Roessler, Stephanie, Wakelam, Michael J.O., McKeating, Jane A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2017 Elsevier Science Ltd Elsevier
Subjects:	Aerospace medicine Animals Autotaxin Cell Line Gastroenterology and Hepatology Gene expression Genes Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C virus Hepatitis C, Chronic - complications Hepatocellular carcinoma Human health and pathology Humans Hypoxia Hypoxia-Inducible Factor 1, alpha subunit Hypoxia-Inducible Factor 1, alpha Subunit - physiology Hépatology and Gastroenterology Life cycles Life Sciences Lipid signalling Liver diseases Liver Neoplasms - etiology Lysophosphatidic acid Mice Phospholipase Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - physiology Promoter Regions, Genetic Receptors, Lysophosphatidic Acid - physiology Replication RNA, Messenger - analysis Signal Transduction Transcription factors Tumorigenesis Tumors Virus Replication Viruses Hypoxia Lysophosphatidic acid Hepatitis C virus Lipid signalling Autotaxin Hypoxia-Inducible Factor 1, alpha subunit
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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