Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis

The lymphatic system provides important functions for tissue fluid homeostasis and immune response. Lymphangiogenesis, the formation of new lymphatics, comprises a series of complex cellular events in vitro or in vivo, e.g., proliferation, differentiation, and sprouting. Recent evidence has implied...

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Vydáno v:	Cellular and molecular life sciences : CMLS Ročník 69; číslo 6; s. 897 - 914
Hlavní autor:	Ji, Rui-Cheng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel SP Birkhäuser Verlag Basel 01.03.2012 Springer Nature B.V
Témata:	Angiogenesis Animals Antigens, CD - physiology Biochemistry Biomedical and Life Sciences Biomedicine Bone marrow CD11b antigen Cell Adhesion Molecules - physiology Cell Adhesion Molecules, Neuronal - physiology Cell Biology Cells Homeostasis Humans Immune response Inflammation Inflammation - physiopathology Lectins, C-Type - physiology Life Sciences Lymphangiogenesis Lymphatic system Lymphocyte receptors Macrophage Activation Macrophage colony-stimulating factor Macrophages Macrophages - physiology Malignancy Mannose Receptor Mannose-Binding Lectins - physiology Neoplasms - physiopathology NF-κB protein Phenotypes Receptors, Cell Surface - physiology Receptors, CXCR4 - physiology Receptors, Lymphocyte Homing - physiology Review SDF-1 protein Signal Transduction Toll-Like Receptor 4 - physiology Tumor Microenvironment Tumor necrosis factor-α Tumors Vascular endothelial growth factor Vascular endothelial growth factor C Vascular Endothelial Growth Factor C - physiology Vascular Endothelial Growth Factor Receptor-3 - physiology Lymphatic endothelial cells VEGFR-2/-3 Tumor Inflammation Macrophages Lymphangiogenesis VEGF-A/-C/-D
ISSN:	1420-682X, 1420-9071, 1420-9071
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Popis
Shrnutí:	The lymphatic system provides important functions for tissue fluid homeostasis and immune response. Lymphangiogenesis, the formation of new lymphatics, comprises a series of complex cellular events in vitro or in vivo, e.g., proliferation, differentiation, and sprouting. Recent evidence has implied that macrophages act as a direct structural contributor to lymphatic endothelial walls or secret VEGF-C/-D and VEGF-A to initiate lymphangiogenesis in inflamed or tumor tissues. Bone marrow-derived macrophages are versatile cells that express different functional programs in response to exposure to microenvironmental signals, and can be identified by specific expression of a number of proteins, F4/80, CD11b, and CD68. Several causative factors, e.g., NF-κB, IL-1β, TNF-α, SDF-1, M-CSF, especially TonEBP/VEGF-C signaling, may be actively involved in macrophage-induced lymphangiogenesis. Alteration of macrophage phenotype and function has a profound effect on the development and progression of inflammation and malignancy, and macrophage depletion for controlling lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic-associated diseases.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-3
ISSN:	1420-682X 1420-9071 1420-9071
DOI:	10.1007/s00018-011-0848-6